Abstract
Muscle mass is controlled by the balance between muscle synthesis and degradation. Although nutrition is important for the maintenance of muscle mass and growth, the effects of feeding time have remained unclear. In the present study, we aimed to evaluate the effects of day- or night-time-restricted feeding on the muscle volume using muscle atrophy and hypertrophy mouse models. The day- and night-time-restricted feeding was conducted from zeitgeber time 2 (ZT2) to ZT10 and ZT14 to ZT22, respectively. In the unilateral immobilization-induced atrophy model, the decrease in immobilized muscle weight did not significantly change with the feeding time. However, the contralateral non-immobilized muscle weight was lower in the mice fed at day time (inactive phase) than in those fed at night time (active phase). In the overloading-induced hypertrophy model, muscle hypertrophy and protein synthesis were attenuated by day-time feeding. These results suggest that day-time feeding attenuated muscle growth via the inhibition of muscle synthesis. Feeding at an irregular time such as a late-night meal could be detrimental for muscle growth.
| Original language | English |
|---|---|
| Article number | 100099 |
| Journal | Journal of Nutrition and Intermediary Metabolism |
| Volume | 17 |
| DOIs | |
| Publication status | Published - 2019 Sep 1 |
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Keywords
- Feeding time
- Muscle hypertrophy
- Protein synthesis
- Time-restricted feeding
ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism
- Food Science
- Nutrition and Dietetics
Cite this
Effects of day-time feeding on murine skeletal muscle growth and synthesis. / Aoyama, Shinya; Kojima, Shuichi; Sasaki, Keisuke; Shimoda, Takeru; Takahashi, Kengo; Hirooka, Rina; Tahara, Yu; Shibata, Shigenobu.
In: Journal of Nutrition and Intermediary Metabolism, Vol. 17, 100099, 01.09.2019.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effects of day-time feeding on murine skeletal muscle growth and synthesis
AU - Aoyama, Shinya
AU - Kojima, Shuichi
AU - Sasaki, Keisuke
AU - Shimoda, Takeru
AU - Takahashi, Kengo
AU - Hirooka, Rina
AU - Tahara, Yu
AU - Shibata, Shigenobu
PY - 2019/9/1
Y1 - 2019/9/1
N2 - Muscle mass is controlled by the balance between muscle synthesis and degradation. Although nutrition is important for the maintenance of muscle mass and growth, the effects of feeding time have remained unclear. In the present study, we aimed to evaluate the effects of day- or night-time-restricted feeding on the muscle volume using muscle atrophy and hypertrophy mouse models. The day- and night-time-restricted feeding was conducted from zeitgeber time 2 (ZT2) to ZT10 and ZT14 to ZT22, respectively. In the unilateral immobilization-induced atrophy model, the decrease in immobilized muscle weight did not significantly change with the feeding time. However, the contralateral non-immobilized muscle weight was lower in the mice fed at day time (inactive phase) than in those fed at night time (active phase). In the overloading-induced hypertrophy model, muscle hypertrophy and protein synthesis were attenuated by day-time feeding. These results suggest that day-time feeding attenuated muscle growth via the inhibition of muscle synthesis. Feeding at an irregular time such as a late-night meal could be detrimental for muscle growth.
AB - Muscle mass is controlled by the balance between muscle synthesis and degradation. Although nutrition is important for the maintenance of muscle mass and growth, the effects of feeding time have remained unclear. In the present study, we aimed to evaluate the effects of day- or night-time-restricted feeding on the muscle volume using muscle atrophy and hypertrophy mouse models. The day- and night-time-restricted feeding was conducted from zeitgeber time 2 (ZT2) to ZT10 and ZT14 to ZT22, respectively. In the unilateral immobilization-induced atrophy model, the decrease in immobilized muscle weight did not significantly change with the feeding time. However, the contralateral non-immobilized muscle weight was lower in the mice fed at day time (inactive phase) than in those fed at night time (active phase). In the overloading-induced hypertrophy model, muscle hypertrophy and protein synthesis were attenuated by day-time feeding. These results suggest that day-time feeding attenuated muscle growth via the inhibition of muscle synthesis. Feeding at an irregular time such as a late-night meal could be detrimental for muscle growth.
KW - Feeding time
KW - Muscle hypertrophy
KW - Protein synthesis
KW - Time-restricted feeding
UR - http://www.scopus.com/inward/record.url?scp=85070982845&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85070982845&partnerID=8YFLogxK
U2 - 10.1016/j.jnim.2019.100099
DO - 10.1016/j.jnim.2019.100099
M3 - Article
AN - SCOPUS:85070982845
VL - 17
JO - Journal of Nutrition and Intermediary Metabolism
JF - Journal of Nutrition and Intermediary Metabolism
SN - 2352-3859
M1 - 100099
ER -