Effects of exercise on brain function

Role of free radicals

Zsolt Radak, Shuzo Kumagai, Albert W. Taylor, Hisashi Naito, Sataro Goto

Research output: Contribution to journalReview article

78 Citations (Scopus)

Abstract

Reactive oxygen species (ROS) are continuously generated during aerobic metabolism. Certain levels of ROS, which could be dependent on the type of cell, cell age, history of ROS exposure, etc., could facilitate specific cell functions. Indeed, ROS stimulate a number of stress responses and activate gene expression for a wide range of proteins. It is well known that increased levels of ROS are involved in the aging process and the pathogenesis of a number of neurodegenerative diseases. Because of the enhanced sensitivity of the central nervous system to ROS, it is especially important to maintain the normal redox state in different types of neuro cells. In the last decade it became clear that regular exercise beneficially affects brain function as well, and can play an important preventive and therapeutic role in stroke and in Alzheimer's and Parkinson's diseases. The effects of exercise appear to be very complex and could include neurogenesis via neurotrophic factors, increased capillarization, decreased oxidative damage, and increased proteolytic degradation by proteasome and neprilysin. Data from our and other laboratories indicate that exercise-induced modulation of ROS levels plays a role in the protein content and expression of brain-derived neurotrophic factor, tyrosine recepetor kinase B, and cAMP response element binding protein, resulting in better function and increased neurogenesis. The enhanced activities of proteasome and neprilysin result in decreased accumulation of carbonyls and amyloid beta-proteins, as well as improved memory. It appears that exercise-induced modulation of the redox state is an important means by which exercise benefits brain function, increases the resistance against oxidative stress, and facilitates recovery from oxidative stress.

Original languageEnglish
Pages (from-to)942-947
Number of pages6
JournalApplied Physiology, Nutrition and Metabolism
Volume32
Issue number5
DOIs
Publication statusPublished - 2007 Oct 1
Externally publishedYes

Fingerprint

Free Radicals
Reactive Oxygen Species
Brain
Neprilysin
Neurogenesis
Proteasome Endopeptidase Complex
Oxidation-Reduction
Oxidative Stress
Cyclic AMP Response Element-Binding Protein
Amyloid beta-Peptides
Brain-Derived Neurotrophic Factor
Nerve Growth Factors
Neurodegenerative Diseases
Protein-Tyrosine Kinases
Parkinson Disease
Alzheimer Disease
Proteins
Central Nervous System
Stroke
Gene Expression

Keywords

  • Exercise
  • Neurotrophins brain function
  • Oxidative damage
  • Oxidative stress

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Physiology
  • Nutrition and Dietetics
  • Physiology (medical)

Cite this

Effects of exercise on brain function : Role of free radicals. / Radak, Zsolt; Kumagai, Shuzo; Taylor, Albert W.; Naito, Hisashi; Goto, Sataro.

In: Applied Physiology, Nutrition and Metabolism, Vol. 32, No. 5, 01.10.2007, p. 942-947.

Research output: Contribution to journalReview article

Radak, Zsolt ; Kumagai, Shuzo ; Taylor, Albert W. ; Naito, Hisashi ; Goto, Sataro. / Effects of exercise on brain function : Role of free radicals. In: Applied Physiology, Nutrition and Metabolism. 2007 ; Vol. 32, No. 5. pp. 942-947.
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