Effects of five nights under normobaric hypoxia on sleep quality

Masako Hoshikawa, Sunao Uchida, Takuya Osawa, Kazumi Eguchi, Takuma Arimitsu, Yasuhiro Suzuki, Takashi Kawahara

    Research output: Contribution to journalArticle

    2 Citations (Scopus)

    Abstract

    Purpose The purpose of this study was to evaluate the effects of five nights' sleep under normobaric hypoxia on ventilatory acclimatization and sleep quality. Methods Seven men initially slept for six nights under normoxia and then for five nights under normobaric hypoxia equivalent to a 2000-m altitude. Nocturnal polysomnograms (PSGs), arterial blood oxygen saturation (SpO2), and respiratory events were recorded on the first and fifth nights under both conditions. Results The hypoxic ventilatory response (HVR), hypercapnic ventilatory response (HCVR), and resting end-tidal CO2 (resting PETCO2) were measured three times during the experimental period. The duration of slow-wave sleep (SWS: stage N3) and the whole-night delta (1-3 Hz) power of nonrapid eye movement (NREM) sleep EEG decreased on the first night under hypoxia. This hypoxia-induced sleep quality deterioration on the first night was accompanied by a lower mean and minimum SpO2, a longer time spent with SpO2 below 90% (<90% SpO2 time), and more episodes of respiratory disturbance. On the fifth night, the SWS duration and whole-night delta power did not differ between the conditions. Although the mean SpO2 under hypoxia was still lower than under normoxia, the minimum SpO2 increased, and the <90% SpO2 time and number of episodes of respiratory disturbance decreased during the five nights under hypoxia. The HVR increased and resting PETCO2 decreased after five nights under hypoxia. Conclusions The results suggest that five nights under hypoxia improves the sleep quality. This may be derived from improvements of respiratory disturbances, the minimum SpO2, and <90% SpO2 time.

    Original languageEnglish
    Pages (from-to)1512-1518
    Number of pages7
    JournalMedicine and Science in Sports and Exercise
    Volume47
    Issue number7
    DOIs
    Publication statusPublished - 2015 Jul 4

    Fingerprint

    Sleep
    Hypoxia
    Sleep Stages
    Acclimatization
    Eye Movements
    Electroencephalography
    Oxygen

    Keywords

    • ADAPTATION
    • HYPOXIA
    • QUALITY OF SLEEP
    • RESPIRATORY DISTURBANCES

    ASJC Scopus subject areas

    • Orthopedics and Sports Medicine
    • Physical Therapy, Sports Therapy and Rehabilitation

    Cite this

    Hoshikawa, M., Uchida, S., Osawa, T., Eguchi, K., Arimitsu, T., Suzuki, Y., & Kawahara, T. (2015). Effects of five nights under normobaric hypoxia on sleep quality. Medicine and Science in Sports and Exercise, 47(7), 1512-1518. https://doi.org/10.1249/MSS.0000000000000569

    Effects of five nights under normobaric hypoxia on sleep quality. / Hoshikawa, Masako; Uchida, Sunao; Osawa, Takuya; Eguchi, Kazumi; Arimitsu, Takuma; Suzuki, Yasuhiro; Kawahara, Takashi.

    In: Medicine and Science in Sports and Exercise, Vol. 47, No. 7, 04.07.2015, p. 1512-1518.

    Research output: Contribution to journalArticle

    Hoshikawa, M, Uchida, S, Osawa, T, Eguchi, K, Arimitsu, T, Suzuki, Y & Kawahara, T 2015, 'Effects of five nights under normobaric hypoxia on sleep quality', Medicine and Science in Sports and Exercise, vol. 47, no. 7, pp. 1512-1518. https://doi.org/10.1249/MSS.0000000000000569
    Hoshikawa M, Uchida S, Osawa T, Eguchi K, Arimitsu T, Suzuki Y et al. Effects of five nights under normobaric hypoxia on sleep quality. Medicine and Science in Sports and Exercise. 2015 Jul 4;47(7):1512-1518. https://doi.org/10.1249/MSS.0000000000000569
    Hoshikawa, Masako ; Uchida, Sunao ; Osawa, Takuya ; Eguchi, Kazumi ; Arimitsu, Takuma ; Suzuki, Yasuhiro ; Kawahara, Takashi. / Effects of five nights under normobaric hypoxia on sleep quality. In: Medicine and Science in Sports and Exercise. 2015 ; Vol. 47, No. 7. pp. 1512-1518.
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    abstract = "Purpose The purpose of this study was to evaluate the effects of five nights' sleep under normobaric hypoxia on ventilatory acclimatization and sleep quality. Methods Seven men initially slept for six nights under normoxia and then for five nights under normobaric hypoxia equivalent to a 2000-m altitude. Nocturnal polysomnograms (PSGs), arterial blood oxygen saturation (SpO2), and respiratory events were recorded on the first and fifth nights under both conditions. Results The hypoxic ventilatory response (HVR), hypercapnic ventilatory response (HCVR), and resting end-tidal CO2 (resting PETCO2) were measured three times during the experimental period. The duration of slow-wave sleep (SWS: stage N3) and the whole-night delta (1-3 Hz) power of nonrapid eye movement (NREM) sleep EEG decreased on the first night under hypoxia. This hypoxia-induced sleep quality deterioration on the first night was accompanied by a lower mean and minimum SpO2, a longer time spent with SpO2 below 90{\%} (<90{\%} SpO2 time), and more episodes of respiratory disturbance. On the fifth night, the SWS duration and whole-night delta power did not differ between the conditions. Although the mean SpO2 under hypoxia was still lower than under normoxia, the minimum SpO2 increased, and the <90{\%} SpO2 time and number of episodes of respiratory disturbance decreased during the five nights under hypoxia. The HVR increased and resting PETCO2 decreased after five nights under hypoxia. Conclusions The results suggest that five nights under hypoxia improves the sleep quality. This may be derived from improvements of respiratory disturbances, the minimum SpO2, and <90{\%} SpO2 time.",
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    AU - Hoshikawa, Masako

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    AU - Osawa, Takuya

    AU - Eguchi, Kazumi

    AU - Arimitsu, Takuma

    AU - Suzuki, Yasuhiro

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    N2 - Purpose The purpose of this study was to evaluate the effects of five nights' sleep under normobaric hypoxia on ventilatory acclimatization and sleep quality. Methods Seven men initially slept for six nights under normoxia and then for five nights under normobaric hypoxia equivalent to a 2000-m altitude. Nocturnal polysomnograms (PSGs), arterial blood oxygen saturation (SpO2), and respiratory events were recorded on the first and fifth nights under both conditions. Results The hypoxic ventilatory response (HVR), hypercapnic ventilatory response (HCVR), and resting end-tidal CO2 (resting PETCO2) were measured three times during the experimental period. The duration of slow-wave sleep (SWS: stage N3) and the whole-night delta (1-3 Hz) power of nonrapid eye movement (NREM) sleep EEG decreased on the first night under hypoxia. This hypoxia-induced sleep quality deterioration on the first night was accompanied by a lower mean and minimum SpO2, a longer time spent with SpO2 below 90% (<90% SpO2 time), and more episodes of respiratory disturbance. On the fifth night, the SWS duration and whole-night delta power did not differ between the conditions. Although the mean SpO2 under hypoxia was still lower than under normoxia, the minimum SpO2 increased, and the <90% SpO2 time and number of episodes of respiratory disturbance decreased during the five nights under hypoxia. The HVR increased and resting PETCO2 decreased after five nights under hypoxia. Conclusions The results suggest that five nights under hypoxia improves the sleep quality. This may be derived from improvements of respiratory disturbances, the minimum SpO2, and <90% SpO2 time.

    AB - Purpose The purpose of this study was to evaluate the effects of five nights' sleep under normobaric hypoxia on ventilatory acclimatization and sleep quality. Methods Seven men initially slept for six nights under normoxia and then for five nights under normobaric hypoxia equivalent to a 2000-m altitude. Nocturnal polysomnograms (PSGs), arterial blood oxygen saturation (SpO2), and respiratory events were recorded on the first and fifth nights under both conditions. Results The hypoxic ventilatory response (HVR), hypercapnic ventilatory response (HCVR), and resting end-tidal CO2 (resting PETCO2) were measured three times during the experimental period. The duration of slow-wave sleep (SWS: stage N3) and the whole-night delta (1-3 Hz) power of nonrapid eye movement (NREM) sleep EEG decreased on the first night under hypoxia. This hypoxia-induced sleep quality deterioration on the first night was accompanied by a lower mean and minimum SpO2, a longer time spent with SpO2 below 90% (<90% SpO2 time), and more episodes of respiratory disturbance. On the fifth night, the SWS duration and whole-night delta power did not differ between the conditions. Although the mean SpO2 under hypoxia was still lower than under normoxia, the minimum SpO2 increased, and the <90% SpO2 time and number of episodes of respiratory disturbance decreased during the five nights under hypoxia. The HVR increased and resting PETCO2 decreased after five nights under hypoxia. Conclusions The results suggest that five nights under hypoxia improves the sleep quality. This may be derived from improvements of respiratory disturbances, the minimum SpO2, and <90% SpO2 time.

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