Effects of folic acid supplementation on oxidative stress markers: A systematic review and meta‐analysis of randomized controlled trials

Omid Asbaghi, Matin Ghanavati, Damoon Ashtary‐larky, Reza Bagheri, Mahnaz Rezaei Kelishadi, Behzad Nazarian, Michael Nordvall, Alexei Wong, Frédéric Dutheil, Katsuhiko Suzuki, Amirmansour Alavi Naeini

Research output: Contribution to journalReview articlepeer-review

2 Citations (Scopus)

Abstract

(1) Background: This systematic review and meta‐analysis aimed to assess the effects of folic acid supplementation on oxidative stress markers. (2) Methods: Online database including PubMed, Scopus, Web of Science, and Cochrane were searched up to January 2021, to retrieve randomized controlled trials (RCTs) which examined the effect of folic acid supplementation on markers of oxidative stress. Meta‐analyses were carried out using a random‐effects model. I2 index was used to evaluate the heterogeneity of RCTs. (3) Results: Among the initial 2322 studies that were identified from electronic databases search, 13 studies involving 1013 participants were eligible. Pooled effect size from 13 studies indicated that folic acid supplementation elicits a significant rise in serum concentrations of glutathione (GSH) (WMD: 219.01 umol/L, 95% CI 59.30 to 378.71, p = 0.007) and total antioxidant capacity (TAC) (WMD: 91.70 umol/L, 95% CI 40.52 to 142.88, p < 0.001) but has no effect on serum concentrations of nitric oxide (NO) (WMD: 2.61 umol/L, 95% CI −3.48 to 8.72, p = 0.400). In addition, folic acid supplementation significantly reduced serum concentrations of malondialdehyde (MDA) (WMD: −0.13 umol/L, 95% CI −0.24 to −0.02, p = 0.020). (4) Conclusions: This meta‐analysis study suggests that folic acid supplementation may significantly improve markers within the antioxidative defense system by increasing serum concentrations of GSH and TAC and decreasing serum concentrations of MDA.

Original languageEnglish
Article number871
JournalAntioxidants
Volume10
Issue number6
DOIs
Publication statusPublished - 2021 Jun

Keywords

  • Folate
  • Folic acid
  • Meta‐analysis
  • Oxidative stress
  • Supplementation
  • Systematic review

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Molecular Biology
  • Clinical Biochemistry
  • Cell Biology

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