Effects of habitual exercise and candidate gene polymorphisms related to bone on calcaneal quantitative ultrasound in middle-aged and elderly japanese

Hiroyuki Ohkubo, Yoshio Nakata, Michiko Fujimura, Takashi Miyauchi, Motoyuki Iemitsu, Seiji Maeda, Kiyoji Tanaka

Research output: Contribution to journalArticlepeer-review

Abstract

The purpose of this study was to investigate the interaction of habitual exercise and candidate gene polymorphisms related to bone on osteo sono-assessment index (OSI) by quantitative ultrasound (QUS) in middle-aged and elderly Japanese. Participants were classified into exercise group (E; n=172, 62.3 ± 7.7 yr) and sedentary group (S; n=65, 58.6 ± 9.2 yr). The OSI was measured with AOS-100. DNA was extracted from blood, and single nucleotide polymorphism in vitamin D receptor, estrogen receptor α, and transforming growth factor-β I were genotyped by TaqMan assay. Group E had significantly lower body weight and body mass index (BMI) than Group S. In men, although Group E was older than Group S, Group E had significantly higher OSI rather than Group S. There was no significant interaction between habitual exercise and each gene polymorphism on OSI. These results essentially runchanged even when analysis of covariance was applied after adjustment for age, body weight, and BMI. These results suggest habitual exercise and genetic factors have no interaction on OSI in middle-aged and elderly Japanese. Further investigations are needed to prove the interaction of other gene polymorphisms and exercise.

Original languageEnglish
Pages (from-to)421-429
Number of pages9
Journaljapanese journal of physical fitness and sports medicine
Volume58
Issue number4
DOIs
Publication statusPublished - 2009 Aug
Externally publishedYes

Keywords

  • Candidate gene polymorphism
  • Habitual exercise
  • Quantitative ultrasound

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

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