Effects of hypothalamic deafferentation on hormonal facilitation of lordosis in ovariectomized rats

K. Yamanouchi, Y. Arai

    Research output: Contribution to journalArticle

    25 Citations (Scopus)

    Abstract

    Lordosis response in estradiol benzoate (EB)-progesterone (P) primed castrated female rats was studied after 4 types of deafferentation of the medial hypothalamus. Tests were started 4-5 weeks after the brain surgery and ovariectomy. Anterior deafferentation (half-dome cut) at the level behind the suprachiasmatic nucleus (AD-I) and island isolation of the medial basal hypothalamus (MBH island) were highly effective to suppress lordosis response in EB-P primed females. However, the cuts placed dorsal (AD-II) or posterior (AD-III) to the AD-I were without apparent suppressive effect on the EB-P induced display of lordosis. These results suggest that the anterolateral fiber connection with the MBH may participate in lordosis facilitatory mechanisms in EB-P primed females. When reserpine (R) was injected instead of P to EB-primed rats, R effectively facilitated lordosis response in rats with or without the deafferentiation (AD-I or MBH island). This suggests that the MBH is not necessary to facilitate lordosis in EB-R primed rats. The site of action of R in the central nervous system for facilitating lordosis may not be the same as that of P.

    Original languageEnglish
    Pages (from-to)307-312
    Number of pages6
    JournalEndocrinologia Japonica
    Volume26
    Issue number3
    Publication statusPublished - 1979

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    Lordosis
    Islands
    Middle Hypothalamus
    Suprachiasmatic Nucleus
    Reserpine
    Ovariectomy
    Central Nervous System
    estradiol 3-benzoate
    Brain

    ASJC Scopus subject areas

    • Endocrinology

    Cite this

    Effects of hypothalamic deafferentation on hormonal facilitation of lordosis in ovariectomized rats. / Yamanouchi, K.; Arai, Y.

    In: Endocrinologia Japonica, Vol. 26, No. 3, 1979, p. 307-312.

    Research output: Contribution to journalArticle

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    N2 - Lordosis response in estradiol benzoate (EB)-progesterone (P) primed castrated female rats was studied after 4 types of deafferentation of the medial hypothalamus. Tests were started 4-5 weeks after the brain surgery and ovariectomy. Anterior deafferentation (half-dome cut) at the level behind the suprachiasmatic nucleus (AD-I) and island isolation of the medial basal hypothalamus (MBH island) were highly effective to suppress lordosis response in EB-P primed females. However, the cuts placed dorsal (AD-II) or posterior (AD-III) to the AD-I were without apparent suppressive effect on the EB-P induced display of lordosis. These results suggest that the anterolateral fiber connection with the MBH may participate in lordosis facilitatory mechanisms in EB-P primed females. When reserpine (R) was injected instead of P to EB-primed rats, R effectively facilitated lordosis response in rats with or without the deafferentiation (AD-I or MBH island). This suggests that the MBH is not necessary to facilitate lordosis in EB-R primed rats. The site of action of R in the central nervous system for facilitating lordosis may not be the same as that of P.

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