Effects of lutein-containing supplement on visual acuity and vision-related quality of life in the healthy elderly with subjective visual symptoms

Naobumi Hamadate, Yoshiyuki Matsumoto, Mami Tasaki, Kayoko Seto, Tetsuro Yamamoto, Hideyo Yamaguchi, Takashi Nakagawa, Etsushi Yamamoto, Sumio Kondo, Masamaru Inaba, Kazunaga Yazawa

Research output: Contribution to journalArticle

Abstract

Results Intervention with lutein-containing supplement significantly increased BCVA of both eyes (in within-group comparison), whereas placebo showed a similar effect on only the right-side eye without any effect on the left-side eye. For VRQOL, significant improvement was observed in lutein group but was not in placebo group (in within-group comparison).

Methods: Seventeen each subjects were allocated to placebo (placebo group) and lutein-containing supplement (lutein group). Lutein-containing supplement was taken orally for 6 weeks in a daily dose of 1320 mg (30 mg as lutein). Before the start and after the end of 6-week intervention, all subjects underwent determinations of best-spectacle corrected VA (BOVA) and examinations of VRQOL based on vision symptom VAS scores for efficacy evaluation.

Conclusions Lutein-containing supplement is considered to have beneficial effects on the elderly with complaint of depressed VRQOL.

Objectives: To study the potential of lutein-containing supplement to improve visual acuity (VA) and/or vision-related quality of life (VRQOL) in a randomized, double-blind, placebo-controlled trial with the healthy elderly aged 50 to 70 years who complained of subjective vision symptoms.

Original languageEnglish
Pages (from-to)603-612
Number of pages10
JournalJapanese Pharmacology and Therapeutics
Volume42
Issue number8
Publication statusPublished - 2014

Keywords

  • Best-spectacle corrected visual acuity (BCVA)
  • Intervention study
  • Lutein
  • Vision-related quality of life
  • Visual function

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology

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