Effects of microstructure and water on the electrical potentials in bone induced by ultrasound irradiation

H. Tsuneda, S. Matsukawa, S. Takayanagi, K. Mizuno, Takahiko Yanagitani, M. Matsukawa

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The healing mechanism of bone fractures by low intensity pulse ultrasound is yet to be fully understood. There have been many discussions regarding how the high frequency dynamic stress can stimulate numerous cell types through various pathways. As one possible initial process of this mechanism, we focus on the piezoelectricity of bone and demonstrate that bone can generate electrical potentials by ultrasound irradiation in the MHz range. We have fabricated ultrasonic bone transducers using bovine cortical bone as the piezoelectric device. The ultrasonically induced electrical potentials in the transducers change as a function of time during immersed ultrasonic pulse measurements and become stable when the bone is fully wet. In addition, the magnitude of the induced electrical potentials changes owing to the microstructure in the cortical bone. The potentials of transducers with haversian structure bone are higher than those of plexiform structure bone, which informs about the effects of bone microstructure on the piezoelectricity.

Original languageEnglish
Article number073704
JournalApplied Physics Letters
Volume106
Issue number7
DOIs
Publication statusPublished - 2015 Feb 16
Externally publishedYes

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bones
microstructure
irradiation
water
transducers
piezoelectricity
ultrasonics
healing
pulses
cells

ASJC Scopus subject areas

  • Physics and Astronomy (miscellaneous)

Cite this

Effects of microstructure and water on the electrical potentials in bone induced by ultrasound irradiation. / Tsuneda, H.; Matsukawa, S.; Takayanagi, S.; Mizuno, K.; Yanagitani, Takahiko; Matsukawa, M.

In: Applied Physics Letters, Vol. 106, No. 7, 073704, 16.02.2015.

Research output: Contribution to journalArticle

Tsuneda, H. ; Matsukawa, S. ; Takayanagi, S. ; Mizuno, K. ; Yanagitani, Takahiko ; Matsukawa, M. / Effects of microstructure and water on the electrical potentials in bone induced by ultrasound irradiation. In: Applied Physics Letters. 2015 ; Vol. 106, No. 7.
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