Effects of posture on peripheral vascular responses to lower body positive pressure

Takeshi Nishiyasu, Shigeko Hayashida, Asami Kitano, Kei Nagashima, Masashi Ichinose

    Research output: Contribution to journalArticle

    23 Citations (Scopus)

    Abstract

    We tested the hypothesis that peripheral vascular responses (in the lower and upper limbs) to application of lower body positive pressure (LBPP) are dependent on the posture of the subjects. We measured heart rate, stroke volume, mean arterial pressure, leg and forearm blood flow (using the Doppler ultrasound technique), and leg (LVC) and forearm (FVC) vascular conductance in 11 subjects (9 men, 2 women) without and with LBPP (25 and 50 mmHg) in supine and upright postures. Mean arterial pressure increased in proportion to increases in LBPP and was greater in supine than in upright subjects. Heart rate was unchanged when LBPP was applied to supine subjects but was reduced in upright ones. Leg blood flow and LVC were both reduced by LBPP in supine subjects [LVC: 4.8 (SD 4.0), 3.6 (SD 3.5), and 1.4 (SD 1.8) ml·min -1·mmHg-1 before LBPP and during 25 and 50 mmHg LBPP, respectively; P < 0.05] but were increased in upright ones [LVC: 2.0 (SD 1.2), 3.4 (SD 3.4), and 3.0 (SD 2.0) ml·min -1·mmHg-1, respectively; P < 0.05]. Forearm blood flow and FVC both declined when LBPP was applied to supine subjects [FVC: 1.3 (SD 0.6), 1.0 (SD 0.4), and 0.9 (SD 0.6) ml·min -1·mmHg-1, respectively; P < 0.05] but remained unchanged in upright ones [FVC: 0.7 (SD 0.4), 0.7 (SD 0.4), and 0.6 (SD 0.5) ml·min-1·mmHg-1, respectively]. Together, these findings indicate that the leg vascular response to application of LBPP is posture dependent and that the response differs in the lower and upper limbs when subjects assume an upright posture.

    Original languageEnglish
    JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
    Volume293
    Issue number1
    DOIs
    Publication statusPublished - 2007 Jul

    Fingerprint

    Posture
    Blood Vessels
    Pressure
    Leg
    Forearm
    Lower Extremity
    Arterial Pressure
    Heart Rate
    Doppler Ultrasonography
    Stroke Volume

    Keywords

    • Forearm blood flow
    • Head-up tilt
    • Leg blood flow

    ASJC Scopus subject areas

    • Physiology

    Cite this

    Effects of posture on peripheral vascular responses to lower body positive pressure. / Nishiyasu, Takeshi; Hayashida, Shigeko; Kitano, Asami; Nagashima, Kei; Ichinose, Masashi.

    In: American Journal of Physiology - Heart and Circulatory Physiology, Vol. 293, No. 1, 07.2007.

    Research output: Contribution to journalArticle

    Nishiyasu, Takeshi ; Hayashida, Shigeko ; Kitano, Asami ; Nagashima, Kei ; Ichinose, Masashi. / Effects of posture on peripheral vascular responses to lower body positive pressure. In: American Journal of Physiology - Heart and Circulatory Physiology. 2007 ; Vol. 293, No. 1.
    @article{32dc109393c34e43a3053d29320028cf,
    title = "Effects of posture on peripheral vascular responses to lower body positive pressure",
    abstract = "We tested the hypothesis that peripheral vascular responses (in the lower and upper limbs) to application of lower body positive pressure (LBPP) are dependent on the posture of the subjects. We measured heart rate, stroke volume, mean arterial pressure, leg and forearm blood flow (using the Doppler ultrasound technique), and leg (LVC) and forearm (FVC) vascular conductance in 11 subjects (9 men, 2 women) without and with LBPP (25 and 50 mmHg) in supine and upright postures. Mean arterial pressure increased in proportion to increases in LBPP and was greater in supine than in upright subjects. Heart rate was unchanged when LBPP was applied to supine subjects but was reduced in upright ones. Leg blood flow and LVC were both reduced by LBPP in supine subjects [LVC: 4.8 (SD 4.0), 3.6 (SD 3.5), and 1.4 (SD 1.8) ml·min -1·mmHg-1 before LBPP and during 25 and 50 mmHg LBPP, respectively; P < 0.05] but were increased in upright ones [LVC: 2.0 (SD 1.2), 3.4 (SD 3.4), and 3.0 (SD 2.0) ml·min -1·mmHg-1, respectively; P < 0.05]. Forearm blood flow and FVC both declined when LBPP was applied to supine subjects [FVC: 1.3 (SD 0.6), 1.0 (SD 0.4), and 0.9 (SD 0.6) ml·min -1·mmHg-1, respectively; P < 0.05] but remained unchanged in upright ones [FVC: 0.7 (SD 0.4), 0.7 (SD 0.4), and 0.6 (SD 0.5) ml·min-1·mmHg-1, respectively]. Together, these findings indicate that the leg vascular response to application of LBPP is posture dependent and that the response differs in the lower and upper limbs when subjects assume an upright posture.",
    keywords = "Forearm blood flow, Head-up tilt, Leg blood flow",
    author = "Takeshi Nishiyasu and Shigeko Hayashida and Asami Kitano and Kei Nagashima and Masashi Ichinose",
    year = "2007",
    month = "7",
    doi = "10.1152/ajpheart.00462.2006",
    language = "English",
    volume = "293",
    journal = "American Journal of Physiology - Heart and Circulatory Physiology",
    issn = "0363-6135",
    publisher = "American Physiological Society",
    number = "1",

    }

    TY - JOUR

    T1 - Effects of posture on peripheral vascular responses to lower body positive pressure

    AU - Nishiyasu, Takeshi

    AU - Hayashida, Shigeko

    AU - Kitano, Asami

    AU - Nagashima, Kei

    AU - Ichinose, Masashi

    PY - 2007/7

    Y1 - 2007/7

    N2 - We tested the hypothesis that peripheral vascular responses (in the lower and upper limbs) to application of lower body positive pressure (LBPP) are dependent on the posture of the subjects. We measured heart rate, stroke volume, mean arterial pressure, leg and forearm blood flow (using the Doppler ultrasound technique), and leg (LVC) and forearm (FVC) vascular conductance in 11 subjects (9 men, 2 women) without and with LBPP (25 and 50 mmHg) in supine and upright postures. Mean arterial pressure increased in proportion to increases in LBPP and was greater in supine than in upright subjects. Heart rate was unchanged when LBPP was applied to supine subjects but was reduced in upright ones. Leg blood flow and LVC were both reduced by LBPP in supine subjects [LVC: 4.8 (SD 4.0), 3.6 (SD 3.5), and 1.4 (SD 1.8) ml·min -1·mmHg-1 before LBPP and during 25 and 50 mmHg LBPP, respectively; P < 0.05] but were increased in upright ones [LVC: 2.0 (SD 1.2), 3.4 (SD 3.4), and 3.0 (SD 2.0) ml·min -1·mmHg-1, respectively; P < 0.05]. Forearm blood flow and FVC both declined when LBPP was applied to supine subjects [FVC: 1.3 (SD 0.6), 1.0 (SD 0.4), and 0.9 (SD 0.6) ml·min -1·mmHg-1, respectively; P < 0.05] but remained unchanged in upright ones [FVC: 0.7 (SD 0.4), 0.7 (SD 0.4), and 0.6 (SD 0.5) ml·min-1·mmHg-1, respectively]. Together, these findings indicate that the leg vascular response to application of LBPP is posture dependent and that the response differs in the lower and upper limbs when subjects assume an upright posture.

    AB - We tested the hypothesis that peripheral vascular responses (in the lower and upper limbs) to application of lower body positive pressure (LBPP) are dependent on the posture of the subjects. We measured heart rate, stroke volume, mean arterial pressure, leg and forearm blood flow (using the Doppler ultrasound technique), and leg (LVC) and forearm (FVC) vascular conductance in 11 subjects (9 men, 2 women) without and with LBPP (25 and 50 mmHg) in supine and upright postures. Mean arterial pressure increased in proportion to increases in LBPP and was greater in supine than in upright subjects. Heart rate was unchanged when LBPP was applied to supine subjects but was reduced in upright ones. Leg blood flow and LVC were both reduced by LBPP in supine subjects [LVC: 4.8 (SD 4.0), 3.6 (SD 3.5), and 1.4 (SD 1.8) ml·min -1·mmHg-1 before LBPP and during 25 and 50 mmHg LBPP, respectively; P < 0.05] but were increased in upright ones [LVC: 2.0 (SD 1.2), 3.4 (SD 3.4), and 3.0 (SD 2.0) ml·min -1·mmHg-1, respectively; P < 0.05]. Forearm blood flow and FVC both declined when LBPP was applied to supine subjects [FVC: 1.3 (SD 0.6), 1.0 (SD 0.4), and 0.9 (SD 0.6) ml·min -1·mmHg-1, respectively; P < 0.05] but remained unchanged in upright ones [FVC: 0.7 (SD 0.4), 0.7 (SD 0.4), and 0.6 (SD 0.5) ml·min-1·mmHg-1, respectively]. Together, these findings indicate that the leg vascular response to application of LBPP is posture dependent and that the response differs in the lower and upper limbs when subjects assume an upright posture.

    KW - Forearm blood flow

    KW - Head-up tilt

    KW - Leg blood flow

    UR - http://www.scopus.com/inward/record.url?scp=34547100286&partnerID=8YFLogxK

    UR - http://www.scopus.com/inward/citedby.url?scp=34547100286&partnerID=8YFLogxK

    U2 - 10.1152/ajpheart.00462.2006

    DO - 10.1152/ajpheart.00462.2006

    M3 - Article

    C2 - 17351071

    AN - SCOPUS:34547100286

    VL - 293

    JO - American Journal of Physiology - Heart and Circulatory Physiology

    JF - American Journal of Physiology - Heart and Circulatory Physiology

    SN - 0363-6135

    IS - 1

    ER -