Effects of prolyl endopeptidase inhibitors and neuropeptides on delayed neuronal death in rats

Yoshiyuki Shishido, Masayoshi Furushiro, Shuichi Tanabe, Shigenobu Shibata, Shusuke Hashimoto, Teruo Yokokura

    Research output: Contribution to journalArticle

    37 Citations (Scopus)

    Abstract

    We investigated the effects of the prolyl endopeptidase inhibitors 1-[1-(Benzyloxycarbonyl)-l-prolyl]prolinal (Z-Pro-Prolinal) and N-benzyloxycarbonyl-thioprolyl-thioprolinal-dimethylacetal (ZTTA) on delayed neuronal death induced by four-vessel-occlusion transient ischemia in rats. We also examined the effects of [pGlu4, Cyt6, Arg8]vasopressin (vasopressin-(4-9)) and thyrotropin-releasing hormone (TRH) on the delayed neuronal death. Furthermore, we investigated the role of vasopressin receptors in the effects of vasopressin and prolyl endopeptidase inhibitors. Z-Pro-Prolinal, vasopressin-(4-9) and TRH protected pyramidal cells in the CA1 subfield of the rat hippocampus from delayed neuronal death after 10-min ischemia. The effect of vasopressin-(4-9) was abolished by vasopressin receptor antagonists. The effect of Z-Pro-Prolinal was also abrogated by the antagonists. These results suggest that the neuroprotective effect of prolyl endopeptidase inhibitors is mediated by neuropeptides such as [Arg8]vasopressin and TRH, and indicate the involvement of vasopressin receptors in the neuroprotective effect of vasopressin-(4-9) and prolyl endopeptidase inhibitors. Copyright (C) 1999 Elsevier Science B.V.

    Original languageEnglish
    Pages (from-to)135-142
    Number of pages8
    JournalEuropean Journal of Pharmacology
    Volume372
    Issue number2
    DOIs
    Publication statusPublished - 1999 May 14

    Fingerprint

    prolyl oligopeptidase
    Protease Inhibitors
    Neuropeptides
    Vasopressins
    Thyrotropin-Releasing Hormone
    Vasopressin Receptors
    Neuroprotective Agents
    Ischemia
    Pyramidal Cells
    Hippocampus

    Keywords

    • Ischemia
    • Neuronal death, delayed
    • Prolyl endopeptidase inhibitor
    • Pyramidal cell
    • Vasopressin-(4-9)
    • Z-Pro-Prolinal
    • ZTTA (N-benzyloxycarbonyl-thioprolyl-thioprolinal-dimethylacetal)

    ASJC Scopus subject areas

    • Cellular and Molecular Neuroscience
    • Pharmacology

    Cite this

    Effects of prolyl endopeptidase inhibitors and neuropeptides on delayed neuronal death in rats. / Shishido, Yoshiyuki; Furushiro, Masayoshi; Tanabe, Shuichi; Shibata, Shigenobu; Hashimoto, Shusuke; Yokokura, Teruo.

    In: European Journal of Pharmacology, Vol. 372, No. 2, 14.05.1999, p. 135-142.

    Research output: Contribution to journalArticle

    Shishido, Yoshiyuki ; Furushiro, Masayoshi ; Tanabe, Shuichi ; Shibata, Shigenobu ; Hashimoto, Shusuke ; Yokokura, Teruo. / Effects of prolyl endopeptidase inhibitors and neuropeptides on delayed neuronal death in rats. In: European Journal of Pharmacology. 1999 ; Vol. 372, No. 2. pp. 135-142.
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