Effects of psychological stress on neutrophil phagocytosis and bactericidal activity in humans a meta-analysis

Kazumasa Tsukamoto, Kazuhiko Machida

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Several authors have reviewed the effects of psychological stress on lymphocyte activity. However the effect of psychological stress on neutrophil functions has not been reviewed. The present meta-analysis summarizes evidence of the effects of psychological stress on neutrophil phagocytosis and bactericidal activity collated from a MEDLINE search of the English literature. We searched the database to identify the relevant studies through April 30, 2013. Eleven studies met our inclusion criteria and we divided them into those addressing transient acute stress (3 studies, n. =. 74), academic examinations (4 studies n. =. 101) and chronic stress/life events (4 studies, n. =. 193). We performed a meta-analysis of the data and calculated total standardized mean differences (SMD) to evaluate the effects of chronic stress. Transient acute stressors might both enhance and decrease these neutrophil functions. Academic examinations tended to elevate neutrophil functions. On the other hand, the total SMDs of neutrophil phagocytosis and bactericidal activity altered by chronic stress/life events were -. 0.589 (95% CI: -. 0.908 to -. 0.270, p. <. 0.05) and -. 0.547 (95% CI: -. 0.845 to -. 0.248, p. <. 0.05), respectively, indicating suppressive effects on these neutrophil functions. Further systematic review of more pooled studies is warranted to confirm that academic examinations might enhance, whereas chronic stress/life events might suppress these neutrophil functions.

Original languageEnglish
Pages (from-to)67-72
Number of pages6
JournalInternational Journal of Psychophysiology
Volume91
Issue number2
DOIs
Publication statusPublished - 2014 Feb

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Keywords

  • Cytokine
  • Immune system
  • Lifestyle
  • Phagocytosis
  • Superoxide

ASJC Scopus subject areas

  • Neuroscience(all)
  • Physiology (medical)
  • Neuropsychology and Physiological Psychology

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