Effects of surface roughness on mechanical hemolysis

Mitsuo Umezu, Takashi Yamada, Hiromi Fujimasu, Tetsuo Fujimoto, Manoja Ranawake, Atsuhiko Nogawa, Toshihiko Kijima

    Research output: Contribution to journalArticle

    23 Citations (Scopus)

    Abstract

    Previous in vitro hemolysis test results showed that an inlet taper or a round corner in the leading edge of a stenotic connector played an important role in the reduction of hemolysis. However, computational fluid dynamics (CFD) analysis of these results indicated that the shear rate and hemolysis level were not always related to each other. Then, further research was performed, focusing on the effects of surface roughness on hemolysis. The results thus far can be summarized as threefold. First, the rate of hemolysis occurring at an abrupt change in the stenotic section was different if the longitudinal length of the stenosis was changed. The level of plasma-free hemoglobin after 6 h of circulation was decreased from 280 mg/dl to 70 mg/dl when the longitudinal length was shortened from 15 mm to 1 mm. Second, a comparison of hemolysis rates in identical stenotic connectors with differing surface roughness (Ra = 0.45 and 1.35 μm) revealed that a smooth surface achieved as much as an 80% reduction in the rate of hemolysis. Third, the in vitro hemolysis results obtained were further defined through CFD analysis.

    Original languageEnglish
    Pages (from-to)575-578
    Number of pages4
    JournalArtificial Organs
    Volume20
    Issue number6
    Publication statusPublished - 1996

    Fingerprint

    Hemolysis
    Dynamic analysis
    Computational fluid dynamics
    Surface roughness
    Hemoglobin
    Shear deformation
    Hemoglobins
    Plasmas
    Hydrodynamics
    Pathologic Constriction
    Research

    Keywords

    • Computational fluid dynamics (CFD) analysis
    • Hemolysis
    • In vitro testing
    • Reattachment point
    • Surface roughness

    ASJC Scopus subject areas

    • Biophysics

    Cite this

    Umezu, M., Yamada, T., Fujimasu, H., Fujimoto, T., Ranawake, M., Nogawa, A., & Kijima, T. (1996). Effects of surface roughness on mechanical hemolysis. Artificial Organs, 20(6), 575-578.

    Effects of surface roughness on mechanical hemolysis. / Umezu, Mitsuo; Yamada, Takashi; Fujimasu, Hiromi; Fujimoto, Tetsuo; Ranawake, Manoja; Nogawa, Atsuhiko; Kijima, Toshihiko.

    In: Artificial Organs, Vol. 20, No. 6, 1996, p. 575-578.

    Research output: Contribution to journalArticle

    Umezu, M, Yamada, T, Fujimasu, H, Fujimoto, T, Ranawake, M, Nogawa, A & Kijima, T 1996, 'Effects of surface roughness on mechanical hemolysis', Artificial Organs, vol. 20, no. 6, pp. 575-578.
    Umezu M, Yamada T, Fujimasu H, Fujimoto T, Ranawake M, Nogawa A et al. Effects of surface roughness on mechanical hemolysis. Artificial Organs. 1996;20(6):575-578.
    Umezu, Mitsuo ; Yamada, Takashi ; Fujimasu, Hiromi ; Fujimoto, Tetsuo ; Ranawake, Manoja ; Nogawa, Atsuhiko ; Kijima, Toshihiko. / Effects of surface roughness on mechanical hemolysis. In: Artificial Organs. 1996 ; Vol. 20, No. 6. pp. 575-578.
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