Effects of systemic hypoxia on human muscular adaptations to resistance exercise training

Michihiro Kon, Nao Ohiwa, Akiko Honda, Takeo Matsubayashi, Tatsuaki Ikeda, Takayuki Akimoto, Yasuhiro Suzuki, Yuichi Hirano, Aaron P. Russell

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

Hypoxia is an important modulator of endurance exercise-induced oxidative adaptations in skeletal muscle. However, whether hypoxia affects resistance exercise-induced muscle adaptations remains unknown. Here, we determined the effect of resistance exercise training under systemic hypoxia on muscular adaptations known to occur following both resistance and endurance exercise training, including muscle cross-sectional area (CSA), one-repetition maximum (1RM), muscular endurance, and makers of mitochondrial biogenesis and angiogenesis, such as peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α), citrate synthase (CS) activity, nitric oxide synthase (NOS), vascular endothelial growth factor (VEGF), hypoxia-inducible factor-1 (HIF-1), and capillary-to-fiber ratio. Sixteen healthy male subjects were randomly assigned to either a normoxic resistance training group (NRT, n = 7) or a hypoxic (14.4% oxygen) resistance training group (HRT, n = 9) and performed 8 weeks of resistance training. Blood and muscle biopsy samples were obtained before and after training. After training muscle CSA of the femoral region, 1RM for bench-press and leg-press, muscular endurance, and skeletal muscle VEGF protein levels significantly increased in both groups. The increase in muscular endurance was significantly higher in the HRT group. Plasma VEGF concentration and skeletal muscle capillary-to-fiber ratio were significantly higher in the HRT group than the NRT group following training. Our results suggest that, in addition to increases in muscle size and strength, HRT may also lead to increased muscular endurance and the promotion of angiogenesis in skeletal muscle.

Original languageEnglish
Article numbere12033
JournalPhysiological Reports
Volume2
Issue number6
DOIs
Publication statusPublished - 2014
Externally publishedYes

Fingerprint

Resistance Training
Skeletal Muscle
Exercise
Vascular Endothelial Growth Factor A
Muscles
Hypoxia-Inducible Factor 1
Citrate (si)-Synthase
Peroxisome Proliferator-Activated Receptors
Muscle Strength
Organelle Biogenesis
Thigh
Nitric Oxide Synthase
Leg
Healthy Volunteers
Oxygen
Biopsy
Hypoxia
Proteins

Keywords

  • Capillarization
  • Resistance exercise training
  • Skeletal muscle
  • Systemic hypoxia

ASJC Scopus subject areas

  • Physiology (medical)
  • Physiology

Cite this

Kon, M., Ohiwa, N., Honda, A., Matsubayashi, T., Ikeda, T., Akimoto, T., ... Russell, A. P. (2014). Effects of systemic hypoxia on human muscular adaptations to resistance exercise training. Physiological Reports, 2(6), [e12033]. https://doi.org/10.14814/phy2.12033

Effects of systemic hypoxia on human muscular adaptations to resistance exercise training. / Kon, Michihiro; Ohiwa, Nao; Honda, Akiko; Matsubayashi, Takeo; Ikeda, Tatsuaki; Akimoto, Takayuki; Suzuki, Yasuhiro; Hirano, Yuichi; Russell, Aaron P.

In: Physiological Reports, Vol. 2, No. 6, e12033, 2014.

Research output: Contribution to journalArticle

Kon, M, Ohiwa, N, Honda, A, Matsubayashi, T, Ikeda, T, Akimoto, T, Suzuki, Y, Hirano, Y & Russell, AP 2014, 'Effects of systemic hypoxia on human muscular adaptations to resistance exercise training', Physiological Reports, vol. 2, no. 6, e12033. https://doi.org/10.14814/phy2.12033
Kon, Michihiro ; Ohiwa, Nao ; Honda, Akiko ; Matsubayashi, Takeo ; Ikeda, Tatsuaki ; Akimoto, Takayuki ; Suzuki, Yasuhiro ; Hirano, Yuichi ; Russell, Aaron P. / Effects of systemic hypoxia on human muscular adaptations to resistance exercise training. In: Physiological Reports. 2014 ; Vol. 2, No. 6.
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