Abstract
Green tea polyphenols, particularly catechins, decrease fasting and postprandial glucose. However, no studies have compared the timing of green tea ingestion on glucose metabolism and changes in catechin concentrations. Here, we examined the effects of timing of acute catechin-rich green tea ingestion on postprandial glucose metabolism in young men. Seventeen healthy young men completed four trials involving blood collection in a fasting state and at 30, 60, 120, and 180 min after meal consumption in a random order: 1) morning placebo trial (09:00 h; MP trial), 2) evening placebo trial (17:00 h; EP trial), 3) morning catechin-rich green tea trial (09:00 h; MGT trial), and 4) evening catechin-rich green tea trial (17:00 h; EGT trial). The concentrations of glucose at 120 min (P=.031) and 180 min (P=.013) after meal intake were significantly higher in the MGT trials than in the MP trials. Additionally, the concentration of glucose was significantly lower in EGT trials than in the EP trials at 60 min (P=.014). Moreover, the concentrations of glucose-dependent insulinotropic polypeptide were significantly lower in the green tea trials than in the placebo trials at 30 min (morning: P=.010, evening: P=.006) and 60 min (morning: P=.001, evening: P=.006) after meal intake in both the morning and evening trials. Our study demonstrated that acute ingestion of catechin-rich green tea in the evening reduced postprandial plasma glucose concentrations.
| Original language | English |
|---|---|
| Article number | 108221 |
| Journal | Journal of Nutritional Biochemistry |
| Volume | 73 |
| DOIs | |
| Publication status | Published - 2019 Nov 1 |
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Keywords
- Circadian rhythm
- Epigallocatechin gallate
- Glucose metabolism
- Incretin
- Meal timing
ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism
- Biochemistry
- Molecular Biology
- Nutrition and Dietetics
- Clinical Biochemistry
Cite this
Effects of timing of acute catechin-rich green tea ingestion on postprandial glucose metabolism in healthy men. / Takahashi, Masaki; Ozaki, Mamiho; Miyashita, Masashi; Fukazawa, Mayuko; Nakaoka, Takashi; Wakisaka, Takuya; Matsui, Yuji; Hibi, Masanobu; Osaki, Noriko; Shibata, Shigenobu.
In: Journal of Nutritional Biochemistry, Vol. 73, 108221, 01.11.2019.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effects of timing of acute catechin-rich green tea ingestion on postprandial glucose metabolism in healthy men
AU - Takahashi, Masaki
AU - Ozaki, Mamiho
AU - Miyashita, Masashi
AU - Fukazawa, Mayuko
AU - Nakaoka, Takashi
AU - Wakisaka, Takuya
AU - Matsui, Yuji
AU - Hibi, Masanobu
AU - Osaki, Noriko
AU - Shibata, Shigenobu
PY - 2019/11/1
Y1 - 2019/11/1
N2 - Green tea polyphenols, particularly catechins, decrease fasting and postprandial glucose. However, no studies have compared the timing of green tea ingestion on glucose metabolism and changes in catechin concentrations. Here, we examined the effects of timing of acute catechin-rich green tea ingestion on postprandial glucose metabolism in young men. Seventeen healthy young men completed four trials involving blood collection in a fasting state and at 30, 60, 120, and 180 min after meal consumption in a random order: 1) morning placebo trial (09:00 h; MP trial), 2) evening placebo trial (17:00 h; EP trial), 3) morning catechin-rich green tea trial (09:00 h; MGT trial), and 4) evening catechin-rich green tea trial (17:00 h; EGT trial). The concentrations of glucose at 120 min (P=.031) and 180 min (P=.013) after meal intake were significantly higher in the MGT trials than in the MP trials. Additionally, the concentration of glucose was significantly lower in EGT trials than in the EP trials at 60 min (P=.014). Moreover, the concentrations of glucose-dependent insulinotropic polypeptide were significantly lower in the green tea trials than in the placebo trials at 30 min (morning: P=.010, evening: P=.006) and 60 min (morning: P=.001, evening: P=.006) after meal intake in both the morning and evening trials. Our study demonstrated that acute ingestion of catechin-rich green tea in the evening reduced postprandial plasma glucose concentrations.
AB - Green tea polyphenols, particularly catechins, decrease fasting and postprandial glucose. However, no studies have compared the timing of green tea ingestion on glucose metabolism and changes in catechin concentrations. Here, we examined the effects of timing of acute catechin-rich green tea ingestion on postprandial glucose metabolism in young men. Seventeen healthy young men completed four trials involving blood collection in a fasting state and at 30, 60, 120, and 180 min after meal consumption in a random order: 1) morning placebo trial (09:00 h; MP trial), 2) evening placebo trial (17:00 h; EP trial), 3) morning catechin-rich green tea trial (09:00 h; MGT trial), and 4) evening catechin-rich green tea trial (17:00 h; EGT trial). The concentrations of glucose at 120 min (P=.031) and 180 min (P=.013) after meal intake were significantly higher in the MGT trials than in the MP trials. Additionally, the concentration of glucose was significantly lower in EGT trials than in the EP trials at 60 min (P=.014). Moreover, the concentrations of glucose-dependent insulinotropic polypeptide were significantly lower in the green tea trials than in the placebo trials at 30 min (morning: P=.010, evening: P=.006) and 60 min (morning: P=.001, evening: P=.006) after meal intake in both the morning and evening trials. Our study demonstrated that acute ingestion of catechin-rich green tea in the evening reduced postprandial plasma glucose concentrations.
KW - Circadian rhythm
KW - Epigallocatechin gallate
KW - Glucose metabolism
KW - Incretin
KW - Meal timing
UR - http://www.scopus.com/inward/record.url?scp=85072207382&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85072207382&partnerID=8YFLogxK
U2 - 10.1016/j.jnutbio.2019.108221
DO - 10.1016/j.jnutbio.2019.108221
M3 - Article
C2 - 31522082
AN - SCOPUS:85072207382
VL - 73
JO - Journal of Nutritional Biochemistry
JF - Journal of Nutritional Biochemistry
SN - 0955-2863
M1 - 108221
ER -