Effects of two types of inactivity on the number of white blood cells in rats

Ken Shirato, Norio Motohashi, Jun Tanihata, Kaoru Tachiyashiki, Akio Tomoda, Kazuhiko Imaizumi

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    20 Citations (Scopus)

    Abstract

    Prolonged inactivity is known to induce changes in responses of many physiological defense systems such as the hypothalamo-hypophyseal-adrenocortical axis, the sympathetic nervous system, and immuno-responsive systems. However, effects of various types of inactivity on immuno-responsive systems are still unknown. Therefore, the effects of two types of inactivity (immobilization: IMM and whole body suspension: WBS) on the number of white blood cells were studied in rats. Rats were divided into the control group and each inactivity group to compare the number of total white blood cells, lymphocytes, monocyte, neutrophil, eosinophil, and basophil during the experimental periods. Both IMM and WBS were maintained for 11 days. IMM markedly increased the number of total white blood cells, monocyte, neutrophil, and eosinophil in the 1st to 10th day. However, the number of total white blood cells, monocyte, neutrophil, and eosinophil during the experiment of WBS were characterized by the presence of a lag phase followed by the significant increased actions. IMM did not change the number of basophil during the experimental period. However, WBS increased the number of basophil in the 1st to 8th day to 2.8-4.8 times, compared with the values of the control. Both IMM and WBS did not change the number of lymphocytes. From these results, WBS increases the number of natural immunity cells without changing acquired immunity cells, and there are different responses in the number of total white blood cells, monocyte, neutrophil, eosinophil, and basophil between IMM and WBS.

    Original languageEnglish
    Pages (from-to)590-600
    Number of pages11
    JournalEuropean Journal of Applied Physiology
    Volume98
    Issue number6
    DOIs
    Publication statusPublished - 2006 Dec

    Keywords

    • Immobilization
    • Immuno-responsive system
    • Inactivity
    • White blood cells
    • Whole body suspension

    ASJC Scopus subject areas

    • Public Health, Environmental and Occupational Health
    • Physiology
    • Orthopedics and Sports Medicine
    • Physical Therapy, Sports Therapy and Rehabilitation

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  • Cite this

    Shirato, K., Motohashi, N., Tanihata, J., Tachiyashiki, K., Tomoda, A., & Imaizumi, K. (2006). Effects of two types of inactivity on the number of white blood cells in rats. European Journal of Applied Physiology, 98(6), 590-600. https://doi.org/10.1007/s00421-006-0306-6