Effects of voluntary wheel running on health indexes in rats with SRBC- induced inflammation

Y. Ina, K. Machida, Katsuhiko Suzuki, K. Tsukamoto

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Abstract

The effects of voluntary running exercise on health indexes in rats were studied before and after Sheep Red Blood Cell (SRBC)-induced inflammation. Male Fischer rats (SPF) 8 weeks of age were housed in individual sedentary cages (sedentary group) or in individual wheel-running cages (exercise group) for 4 months. Then all rats were injected with 20% SRBC (0.5ml/100g body weight) i.p. Voluntary running activity averaged 1408m/day, reached a peak (2913m/day) at the 25th day and waned over time, reaching a plateau at the 60th day (about 1000m/day). In spite of a significant increase in food intake (117%), exercising rats gained significantly less weight (93%) than sedentary rats at all times in experimental period. The exercise group also showed a significant decrease in the value of serum triglyceride (TG) and total cholesterol (T. CHO) (TG p<0.0002, T. CHO p<0.03). The hematocrit (Ht) and hemoglobin concentration (Hb) were higher in the exercised rats, and at 4 days after i.p. SRBC, the difference became statistically significant (Ht p<0.0002, Hb p<0.003). Thus, protective effects against the decrease of Ht and Hb were demonstrated in the exercised group. Perhaps this inflammation did not impair liver function severely; sedentary rats had normal or slightly higher levels of GOT and GPT. On the other hand, exercised rats had lower GOT and GPT. Significant differences were found between the groups (GOT, GPT p<0.0001).

Original languageEnglish
Pages (from-to)1077-1089
Number of pages13
JournalJapanese Journal of Hygiene
Volume48
Issue number6
Publication statusPublished - 1993

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Running
Sheep
Erythrocytes
Inflammation
Health
Hematocrit
Triglycerides
Cholesterol
Inbred F344 Rats
Hemoglobins
Eating
Body Weight
Weights and Measures
Liver
Serum

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

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Effects of voluntary wheel running on health indexes in rats with SRBC- induced inflammation. / Ina, Y.; Machida, K.; Suzuki, Katsuhiko; Tsukamoto, K.

In: Japanese Journal of Hygiene, Vol. 48, No. 6, 1993, p. 1077-1089.

Research output: Contribution to journalArticle

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abstract = "The effects of voluntary running exercise on health indexes in rats were studied before and after Sheep Red Blood Cell (SRBC)-induced inflammation. Male Fischer rats (SPF) 8 weeks of age were housed in individual sedentary cages (sedentary group) or in individual wheel-running cages (exercise group) for 4 months. Then all rats were injected with 20{\%} SRBC (0.5ml/100g body weight) i.p. Voluntary running activity averaged 1408m/day, reached a peak (2913m/day) at the 25th day and waned over time, reaching a plateau at the 60th day (about 1000m/day). In spite of a significant increase in food intake (117{\%}), exercising rats gained significantly less weight (93{\%}) than sedentary rats at all times in experimental period. The exercise group also showed a significant decrease in the value of serum triglyceride (TG) and total cholesterol (T. CHO) (TG p<0.0002, T. CHO p<0.03). The hematocrit (Ht) and hemoglobin concentration (Hb) were higher in the exercised rats, and at 4 days after i.p. SRBC, the difference became statistically significant (Ht p<0.0002, Hb p<0.003). Thus, protective effects against the decrease of Ht and Hb were demonstrated in the exercised group. Perhaps this inflammation did not impair liver function severely; sedentary rats had normal or slightly higher levels of GOT and GPT. On the other hand, exercised rats had lower GOT and GPT. Significant differences were found between the groups (GOT, GPT p<0.0001).",
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