Eight new cytotoxic metabolites closely related to onnamide A from two marine sponges of the genus Theonella

Shigeki Matsunaga, Nobuhiro Fusetani, Youichi Nakao

Research output: Contribution to journalArticle

69 Citations (Scopus)

Abstract

New cytotoxic compounds 1-7 were isolated along with onnamide A (9) from a marine sponge Theonella sp. collected at Hachijo Island, whereas another Theonella sponge yielded 8. The structures of these compounds were determined by interpretation of the NMR spectral data as well as by comparison of spectral data with those of 9. Six compounds (1-6) were highly cytotoxic against the P388 cell line.

Original languageEnglish
Pages (from-to)8369-8376
Number of pages8
JournalTetrahedron
Volume48
Issue number39
DOIs
Publication statusPublished - 1992 Sep 25
Externally publishedYes

Fingerprint

Theonella
Porifera
Metabolites
Cells
Nuclear magnetic resonance
Islands
Cell Line
onnamide

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Cite this

Eight new cytotoxic metabolites closely related to onnamide A from two marine sponges of the genus Theonella. / Matsunaga, Shigeki; Fusetani, Nobuhiro; Nakao, Youichi.

In: Tetrahedron, Vol. 48, No. 39, 25.09.1992, p. 8369-8376.

Research output: Contribution to journalArticle

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