Eight new cytotoxic metabolites closely related to onnamide A from two marine sponges of the genus Theonella

Shigeki Matsunaga, Nobuhiro Fusetani, Youichi Nakao

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Abstract

New cytotoxic compounds 1-7 were isolated along with onnamide A (9) from a marine sponge Theonella sp. collected at Hachijo Island, whereas another Theonella sponge yielded 8. The structures of these compounds were determined by interpretation of the NMR spectral data as well as by comparison of spectral data with those of 9. Six compounds (1-6) were highly cytotoxic against the P388 cell line.

Original languageEnglish
Pages (from-to)8369-8376
Number of pages8
JournalTetrahedron
Volume48
Issue number39
DOIs
Publication statusPublished - 1992 Sep 25

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ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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