Elastic origin of chiral selection in DNA wrapping

Tomohiro Yanao, Kenichi Yoshikawa

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

We investigated the mechanism that underlies the chiral selection on the direction of wrapping of DNA around a nucleosome core particle. A coarse-grained model for the formation of a nucleosome is introduced, in which DNA is treated as a semiflexible polymer and the histone core is modeled by a spherical particle. Asymmetric coupling between bending and twisting is incorporated into the model DNA, which is expected from the double-stranded helical structure of DNA. We show that the tendency of DNA to twist in a left-handed manner upon bending gives rise to the selective left-handed wrapping, provided that the size of the core particle is chosen appropriately. This result suggests the critical importance of the chiral asymmetry inherent in the bending-twisting elasticity of DNA as well as the size of the core in determining the handedness of wrapping in nucleosome formation.

Original languageEnglish
Article number021904
JournalPhysical Review E - Statistical, Nonlinear, and Soft Matter Physics
Volume77
Issue number2
DOIs
Publication statusPublished - 2008 Feb 6
Externally publishedYes

Fingerprint

Left handed
deoxyribonucleic acid
twisting
Twist
Asymmetry
Elasticity
Polymers
handedness
Model
tendencies
elastic properties
asymmetry
polymers

ASJC Scopus subject areas

  • Physics and Astronomy(all)
  • Condensed Matter Physics
  • Statistical and Nonlinear Physics
  • Mathematical Physics

Cite this

Elastic origin of chiral selection in DNA wrapping. / Yanao, Tomohiro; Yoshikawa, Kenichi.

In: Physical Review E - Statistical, Nonlinear, and Soft Matter Physics, Vol. 77, No. 2, 021904, 06.02.2008.

Research output: Contribution to journalArticle

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