Elastic properties of living fibroblasts as imaged using force modulation mode in atomic force microscopy

Shigeo Sasaki, Mayumi Morimoto, Hisashi Haga, Kazushige Kawabata, Etsuro Ito, Tatsuo Ushiki, Kazuhiro Abe, Takashi Sambongi

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Using the force modulation mode in atomic force microscopy, we measured elastic properties of living mouse fibroblasts (NIH3T3) in a culture medium. The topographic images of the cellular surface and the corresponding elastic images of the cellular surface were able to be captured simultaneously with high spatial resolution. The consecutive images were useful for examining time-dependent changes in the cellular surface. We observed that some cells continued to shrink and change their softness for 2 hours. Then the force modulation mode in atomic force microscopy shows potential use in analyzing time-dependent regional elastic properties of living cells with high spatial resolution.

Original languageEnglish
Pages (from-to)57-63
Number of pages7
JournalArchives of Histology and Cytology
Volume61
Issue number1
DOIs
Publication statusPublished - 1998 Mar

ASJC Scopus subject areas

  • Histology

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