@inproceedings{a32c1d25dec4498db40eb1c963444ffd,
title = "Electrical detection of biomolecules in a PDMS micro-fluidic channel using a MOSFET-type biosensor",
abstract = "In this article, we report a MOSFET-type biosensor assembled in a polydimethylsiloxane (PDMS) micro-fluidic channel for the electrical detection of nano-scale biomolecules. The MOSFET-type sensor was fabricated on the basis of standard complementary metal oxide semiconductor (CMOS) technology. Au which has a chemical affinity with thiol by forming a self-assembled monolayer (SAM) was used as the gate metal. In order to apply to the hybrid micro-flow-system for a prototype lab-on-a-chip, the PDMS layer with the micro-channel was aligned along with the sensing area of the MOSFET device. Thiol which was injected into the micro-fluidic channel was detected by measuring the electrical characteristics of the MOSFET sensor in both ex-situ and in-situ due to the negative charge of thiol.",
keywords = "Biosensors, Differential measurement, Field effect transistors, Lab-on-a-chip, Micro-fluidic channel, PDMS, Quasi-reference electrode, Self-assembled monolayers",
author = "Shin, {Jang Kyoo} and Kim, {Dong Sun} and Geunbae Lim and Shuichi Shoji",
year = "2007",
month = apr,
day = "30",
doi = "10.1117/12.696050",
language = "English",
isbn = "0819465240",
series = "Proceedings of SPIE - The International Society for Optical Engineering",
booktitle = "Biomedical Applications of Micro- and Nanoengineering III",
note = "Biomedical Applications of Micro- and Nanoengineering III ; Conference date: 11-12-2006 Through 13-12-2006",
}