Electrical detection of biomolecules in a PDMS micro-fluidic channel using a MOSFET-type biosensor

Jang Kyoo Shin, Dong Sun Kim, Geunbae Lim, Shuichi Shoji

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Citations (Scopus)

Abstract

In this article, we report a MOSFET-type biosensor assembled in a polydimethylsiloxane (PDMS) micro-fluidic channel for the electrical detection of nano-scale biomolecules. The MOSFET-type sensor was fabricated on the basis of standard complementary metal oxide semiconductor (CMOS) technology. Au which has a chemical affinity with thiol by forming a self-assembled monolayer (SAM) was used as the gate metal. In order to apply to the hybrid micro-flow-system for a prototype lab-on-a-chip, the PDMS layer with the micro-channel was aligned along with the sensing area of the MOSFET device. Thiol which was injected into the micro-fluidic channel was detected by measuring the electrical characteristics of the MOSFET sensor in both ex-situ and in-situ due to the negative charge of thiol.

Original languageEnglish
Title of host publicationBiomedical Applications of Micro- and Nanoengineering III
DOIs
Publication statusPublished - 2007 Apr 30
EventBiomedical Applications of Micro- and Nanoengineering III - Adelaide, Australia
Duration: 2006 Dec 112006 Dec 13

Publication series

NameProceedings of SPIE - The International Society for Optical Engineering
Volume6416
ISSN (Print)0277-786X

Conference

ConferenceBiomedical Applications of Micro- and Nanoengineering III
CountryAustralia
CityAdelaide
Period06/12/1106/12/13

Keywords

  • Biosensors
  • Differential measurement
  • Field effect transistors
  • Lab-on-a-chip
  • Micro-fluidic channel
  • PDMS
  • Quasi-reference electrode
  • Self-assembled monolayers

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering

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  • Cite this

    Shin, J. K., Kim, D. S., Lim, G., & Shoji, S. (2007). Electrical detection of biomolecules in a PDMS micro-fluidic channel using a MOSFET-type biosensor. In Biomedical Applications of Micro- and Nanoengineering III [641612] (Proceedings of SPIE - The International Society for Optical Engineering; Vol. 6416). https://doi.org/10.1117/12.696050