Electrical detection of biomolecules in a PDMS micro-fluidic channel using a MOSFET-type biosensor

Jang Kyoo Shin, Dong Sun Kim, Geunbae Lim, Shuichi Shoji

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    2 Citations (Scopus)

    Abstract

    In this article, we report a MOSFET-type biosensor assembled in a polydimethylsiloxane (PDMS) micro-fluidic channel for the electrical detection of nano-scale biomolecules. The MOSFET-type sensor was fabricated on the basis of standard complementary metal oxide semiconductor (CMOS) technology. Au which has a chemical affinity with thiol by forming a self-assembled monolayer (SAM) was used as the gate metal. In order to apply to the hybrid micro-flow-system for a prototype lab-on-a-chip, the PDMS layer with the micro-channel was aligned along with the sensing area of the MOSFET device. Thiol which was injected into the micro-fluidic channel was detected by measuring the electrical characteristics of the MOSFET sensor in both ex-situ and in-situ due to the negative charge of thiol.

    Original languageEnglish
    Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
    Volume6416
    DOIs
    Publication statusPublished - 2007
    EventBiomedical Applications of Micro- and Nanoengineering III - Adelaide
    Duration: 2006 Dec 112006 Dec 13

    Other

    OtherBiomedical Applications of Micro- and Nanoengineering III
    CityAdelaide
    Period06/12/1106/12/13

    Fingerprint

    fluidics
    Fluidics
    Biomolecules
    Polydimethylsiloxane
    bioinstrumentation
    Biosensors
    field effect transistors
    thiols
    Lab-on-a-chip
    Sensors
    MOSFET devices
    Self assembled monolayers
    Metals
    sensors
    affinity
    CMOS
    chips
    prototypes
    metals
    Oxide semiconductors

    Keywords

    • Biosensors
    • Differential measurement
    • Field effect transistors
    • Lab-on-a-chip
    • Micro-fluidic channel
    • PDMS
    • Quasi-reference electrode
    • Self-assembled monolayers

    ASJC Scopus subject areas

    • Electrical and Electronic Engineering
    • Condensed Matter Physics

    Cite this

    Shin, J. K., Kim, D. S., Lim, G., & Shoji, S. (2007). Electrical detection of biomolecules in a PDMS micro-fluidic channel using a MOSFET-type biosensor. In Proceedings of SPIE - The International Society for Optical Engineering (Vol. 6416). [641612] https://doi.org/10.1117/12.696050

    Electrical detection of biomolecules in a PDMS micro-fluidic channel using a MOSFET-type biosensor. / Shin, Jang Kyoo; Kim, Dong Sun; Lim, Geunbae; Shoji, Shuichi.

    Proceedings of SPIE - The International Society for Optical Engineering. Vol. 6416 2007. 641612.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Shin, JK, Kim, DS, Lim, G & Shoji, S 2007, Electrical detection of biomolecules in a PDMS micro-fluidic channel using a MOSFET-type biosensor. in Proceedings of SPIE - The International Society for Optical Engineering. vol. 6416, 641612, Biomedical Applications of Micro- and Nanoengineering III, Adelaide, 06/12/11. https://doi.org/10.1117/12.696050
    Shin JK, Kim DS, Lim G, Shoji S. Electrical detection of biomolecules in a PDMS micro-fluidic channel using a MOSFET-type biosensor. In Proceedings of SPIE - The International Society for Optical Engineering. Vol. 6416. 2007. 641612 https://doi.org/10.1117/12.696050
    Shin, Jang Kyoo ; Kim, Dong Sun ; Lim, Geunbae ; Shoji, Shuichi. / Electrical detection of biomolecules in a PDMS micro-fluidic channel using a MOSFET-type biosensor. Proceedings of SPIE - The International Society for Optical Engineering. Vol. 6416 2007.
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