Electrical potentials in bone induced by ultrasound irradiation in the megahertz range

M. Okino; S. Coutelou; K. Mizuno; T. Yanagitani; M. Matsukawa

doi:10.1063/1.4819853

Electrical potentials in bone induced by ultrasound irradiation in the megahertz range

M. Okino, S. Coutelou, K. Mizuno, T. Yanagitani, M. Matsukawa

Research output: Contribution to journal › Article › peer-review

21 Citations (Scopus)

Abstract

Low frequency mechanical studies have reported the contribution of stress-induced electrical potentials to bone metabolism. However, the healing mechanism of bone fractures by low intensity ultrasound is not yet clear. We demonstrate that bone can generate electrical potentials by ultrasound irradiation in the MHz range. Electrical potentials were obtained from the output of bovine cortical bone transducers. In the range of 0.7-2.5 MHz, sensitivities of bone transducers were around 1/1000 of a poly (vinylidene fluoride) ultrasonic transducer and did not depend on magnitude and alignment of hydroxyapatite crystallites in bone.

Original language	English
Article number	103701
Journal	Applied Physics Letters
Volume	103
Issue number	10
DOIs	https://doi.org/10.1063/1.4819853
Publication status	Published - 2013 Sept 2
Externally published	Yes

ASJC Scopus subject areas

Physics and Astronomy (miscellaneous)

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10.1063/1.4819853

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title = "Electrical potentials in bone induced by ultrasound irradiation in the megahertz range",

abstract = "Low frequency mechanical studies have reported the contribution of stress-induced electrical potentials to bone metabolism. However, the healing mechanism of bone fractures by low intensity ultrasound is not yet clear. We demonstrate that bone can generate electrical potentials by ultrasound irradiation in the MHz range. Electrical potentials were obtained from the output of bovine cortical bone transducers. In the range of 0.7-2.5 MHz, sensitivities of bone transducers were around 1/1000 of a poly (vinylidene fluoride) ultrasonic transducer and did not depend on magnitude and alignment of hydroxyapatite crystallites in bone.",

author = "M. Okino and S. Coutelou and K. Mizuno and T. Yanagitani and M. Matsukawa",

note = "Funding Information: Part of this work was supported by the Regional Innovation Strategy Support Program of the Ministry of Education, Culture, Sports, Science and Technology, Japan and a Grant-in-Aid for Scientific Research (B) from the Japan Society for the Promotion of Science. We gratefully acknowledge the assistance of Mr. Pierre-Louis Toussaint, Mr. Shinji Takayanagi and Ms. Hiroko Tsuneda during experiments.",

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T1 - Electrical potentials in bone induced by ultrasound irradiation in the megahertz range

AU - Okino, M.

AU - Coutelou, S.

AU - Mizuno, K.

AU - Yanagitani, T.

AU - Matsukawa, M.

N1 - Funding Information: Part of this work was supported by the Regional Innovation Strategy Support Program of the Ministry of Education, Culture, Sports, Science and Technology, Japan and a Grant-in-Aid for Scientific Research (B) from the Japan Society for the Promotion of Science. We gratefully acknowledge the assistance of Mr. Pierre-Louis Toussaint, Mr. Shinji Takayanagi and Ms. Hiroko Tsuneda during experiments.

PY - 2013/9/2

Y1 - 2013/9/2

N2 - Low frequency mechanical studies have reported the contribution of stress-induced electrical potentials to bone metabolism. However, the healing mechanism of bone fractures by low intensity ultrasound is not yet clear. We demonstrate that bone can generate electrical potentials by ultrasound irradiation in the MHz range. Electrical potentials were obtained from the output of bovine cortical bone transducers. In the range of 0.7-2.5 MHz, sensitivities of bone transducers were around 1/1000 of a poly (vinylidene fluoride) ultrasonic transducer and did not depend on magnitude and alignment of hydroxyapatite crystallites in bone.

AB - Low frequency mechanical studies have reported the contribution of stress-induced electrical potentials to bone metabolism. However, the healing mechanism of bone fractures by low intensity ultrasound is not yet clear. We demonstrate that bone can generate electrical potentials by ultrasound irradiation in the MHz range. Electrical potentials were obtained from the output of bovine cortical bone transducers. In the range of 0.7-2.5 MHz, sensitivities of bone transducers were around 1/1000 of a poly (vinylidene fluoride) ultrasonic transducer and did not depend on magnitude and alignment of hydroxyapatite crystallites in bone.

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Electrical potentials in bone induced by ultrasound irradiation in the megahertz range

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