Electrochemical detection and sensing of reactive oxygen species

Makoto Yuasa, Kenichi Oyaizu

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Reactive oxygen species (ROS) such as superoxide anion radical (O2 -·) play an essential role on normal cellular growth and homeostasis. However, excess ROS generated by perturbing O2 -· homeostasis under various conditions of oxidative stress induce high radical toxicity, resulting in many diseases such as cancer, brain and myocardial infarction, and inflammation. Quantitative analysis of O2 -· by a convenient method is a subject of intense research, since most of ROS are derived from O2 -·. In situ real-time measurement of O2 -· is very important to understand the relevance of ROS to many diseases. Recent progress in electrochemical sensors for the facile detection of O2 -·, including biosensors utilizing a variety of metalloproteins as sensing elements for O2 -· and very recently developed all-synthetic sensors with a high selectivity for O2 -· detection, is reviewed. Emphasis is placed on the possibility of the all-synthetic sensor for convenient in vivo measurement of ROS.

Original languageEnglish
Pages (from-to)1685-1697
Number of pages13
JournalCurrent Organic Chemistry
Volume9
Issue number16
DOIs
Publication statusPublished - 2005 Nov
Externally publishedYes

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Reactive Oxygen Species
Metalloproteins
Electrochemical sensors
Oxidative stress
Sensors
Time measurement
Biosensors
Superoxides
Toxicity
Brain
Chemical analysis

ASJC Scopus subject areas

  • Organic Chemistry

Cite this

Electrochemical detection and sensing of reactive oxygen species. / Yuasa, Makoto; Oyaizu, Kenichi.

In: Current Organic Chemistry, Vol. 9, No. 16, 11.2005, p. 1685-1697.

Research output: Contribution to journalArticle

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