Abstract
In biological systems, intercellular communication is mediated by membrane proteins and ion channels that regulate traffic of ions and small molecules across cell membranes. A bioelectronic device with ion channels that control ionic flow across a supported lipid bilayer (SLB) should therefore be ideal for interfacing with biological systems. Here, we demonstrate a biotic-abiotic bioprotonic device with Pd contacts that regulates proton (H+) flow across an SLB incorporating the ion channels Gramicidin A (gA) and Alamethicin (ALM). We model the device characteristics using the Goldman-Hodgkin-Katz (GHK) solution to the Nernst-Planck equation for transport across the membrane. We derive the permeability for an SLB integrating gA and ALM and demonstrate pH control as a function of applied voltage and membrane permeability. This work opens the door to integrating more complex H+ channels at the Pd contact interface to produce responsive biotic-abiotic devices with increased functionality.
| Original language | English |
|---|---|
| Article number | 12981 |
| Journal | Nature Communications |
| Volume | 7 |
| DOIs | |
| Publication status | Published - 2016 Oct 7 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Chemistry(all)
- Biochemistry, Genetics and Molecular Biology(all)
- Physics and Astronomy(all)
Cite this
Electronic control of H+ current in a bioprotonic device with Gramicidin A and Alamethicin. / Hemmatian, Zahra; Keene, Scott; Josberger, Erik; Miyake, Takeo; Arboleda, Carina; Soto-Rodríguez, Jessica; Baneyx, François; Rolandi, Marco.
In: Nature Communications, Vol. 7, 12981, 07.10.2016.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Electronic control of H+ current in a bioprotonic device with Gramicidin A and Alamethicin
AU - Hemmatian, Zahra
AU - Keene, Scott
AU - Josberger, Erik
AU - Miyake, Takeo
AU - Arboleda, Carina
AU - Soto-Rodríguez, Jessica
AU - Baneyx, François
AU - Rolandi, Marco
PY - 2016/10/7
Y1 - 2016/10/7
N2 - In biological systems, intercellular communication is mediated by membrane proteins and ion channels that regulate traffic of ions and small molecules across cell membranes. A bioelectronic device with ion channels that control ionic flow across a supported lipid bilayer (SLB) should therefore be ideal for interfacing with biological systems. Here, we demonstrate a biotic-abiotic bioprotonic device with Pd contacts that regulates proton (H+) flow across an SLB incorporating the ion channels Gramicidin A (gA) and Alamethicin (ALM). We model the device characteristics using the Goldman-Hodgkin-Katz (GHK) solution to the Nernst-Planck equation for transport across the membrane. We derive the permeability for an SLB integrating gA and ALM and demonstrate pH control as a function of applied voltage and membrane permeability. This work opens the door to integrating more complex H+ channels at the Pd contact interface to produce responsive biotic-abiotic devices with increased functionality.
AB - In biological systems, intercellular communication is mediated by membrane proteins and ion channels that regulate traffic of ions and small molecules across cell membranes. A bioelectronic device with ion channels that control ionic flow across a supported lipid bilayer (SLB) should therefore be ideal for interfacing with biological systems. Here, we demonstrate a biotic-abiotic bioprotonic device with Pd contacts that regulates proton (H+) flow across an SLB incorporating the ion channels Gramicidin A (gA) and Alamethicin (ALM). We model the device characteristics using the Goldman-Hodgkin-Katz (GHK) solution to the Nernst-Planck equation for transport across the membrane. We derive the permeability for an SLB integrating gA and ALM and demonstrate pH control as a function of applied voltage and membrane permeability. This work opens the door to integrating more complex H+ channels at the Pd contact interface to produce responsive biotic-abiotic devices with increased functionality.
UR - http://www.scopus.com/inward/record.url?scp=84990192883&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84990192883&partnerID=8YFLogxK
U2 - 10.1038/ncomms12981
DO - 10.1038/ncomms12981
M3 - Article
C2 - 27713411
AN - SCOPUS:84990192883
VL - 7
JO - Nature Communications
JF - Nature Communications
SN - 2041-1723
M1 - 12981
ER -