Electronic control of H+ current in a bioprotonic device with Gramicidin A and Alamethicin

Zahra Hemmatian, Scott Keene, Erik Josberger, Takeo Miyake, Carina Arboleda, Jessica Soto-Rodríguez, François Baneyx, Marco Rolandi

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

In biological systems, intercellular communication is mediated by membrane proteins and ion channels that regulate traffic of ions and small molecules across cell membranes. A bioelectronic device with ion channels that control ionic flow across a supported lipid bilayer (SLB) should therefore be ideal for interfacing with biological systems. Here, we demonstrate a biotic-abiotic bioprotonic device with Pd contacts that regulates proton (H+) flow across an SLB incorporating the ion channels Gramicidin A (gA) and Alamethicin (ALM). We model the device characteristics using the Goldman-Hodgkin-Katz (GHK) solution to the Nernst-Planck equation for transport across the membrane. We derive the permeability for an SLB integrating gA and ALM and demonstrate pH control as a function of applied voltage and membrane permeability. This work opens the door to integrating more complex H+ channels at the Pd contact interface to produce responsive biotic-abiotic devices with increased functionality.

Original languageEnglish
Article number12981
JournalNature Communications
Volume7
DOIs
Publication statusPublished - 2016 Oct 7
Externally publishedYes

Fingerprint

Alamethicin
Gramicidin
electronic control
Lipid bilayers
Ion Channels
Lipid Bilayers
Biological systems
lipids
Equipment and Supplies
membranes
Membranes
Permeability
permeability
Cell membranes
Protons
Membrane Proteins
Ions
traffic
telecommunication
Molecules

ASJC Scopus subject areas

  • Chemistry(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Physics and Astronomy(all)

Cite this

Hemmatian, Z., Keene, S., Josberger, E., Miyake, T., Arboleda, C., Soto-Rodríguez, J., ... Rolandi, M. (2016). Electronic control of H+ current in a bioprotonic device with Gramicidin A and Alamethicin. Nature Communications, 7, [12981]. https://doi.org/10.1038/ncomms12981

Electronic control of H+ current in a bioprotonic device with Gramicidin A and Alamethicin. / Hemmatian, Zahra; Keene, Scott; Josberger, Erik; Miyake, Takeo; Arboleda, Carina; Soto-Rodríguez, Jessica; Baneyx, François; Rolandi, Marco.

In: Nature Communications, Vol. 7, 12981, 07.10.2016.

Research output: Contribution to journalArticle

Hemmatian, Z, Keene, S, Josberger, E, Miyake, T, Arboleda, C, Soto-Rodríguez, J, Baneyx, F & Rolandi, M 2016, 'Electronic control of H+ current in a bioprotonic device with Gramicidin A and Alamethicin', Nature Communications, vol. 7, 12981. https://doi.org/10.1038/ncomms12981
Hemmatian, Zahra ; Keene, Scott ; Josberger, Erik ; Miyake, Takeo ; Arboleda, Carina ; Soto-Rodríguez, Jessica ; Baneyx, François ; Rolandi, Marco. / Electronic control of H+ current in a bioprotonic device with Gramicidin A and Alamethicin. In: Nature Communications. 2016 ; Vol. 7.
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