Electrophysiological studies of the development of suprachiasmatic neuronal activity in hypothalamic slice preparations

Shigenobu Shibata; Yutaka Oomura; Shyh Yuh Liou; Showa Ueki

doi:10.1016/0165-3806(84)90074-9

Electrophysiological studies of the development of suprachiasmatic neuronal activity in hypothalamic slice preparations

Shigenobu Shibata, Yutaka Oomura, Shyh Yuh Liou, Showa Ueki

Research output: Contribution to journal › Article › peer-review

21 Citations (Scopus)

Abstract

The rate and pattern of neuronal discharge in the suprachiasmatic nucleus (SCN) during developmental stages were studied and compared with those of the ventromedial (VMH) and the lateral hypothalamus (LHA) using rat hypothalamic slices. The firing rate of the SCN neurons was low on the 7th and 11th days; however, it dramatically increased by the 14th day to reach the adult rate, while firing rates of VMH and LHA neurons increased gradually with age. The discharge rate of neurons in the ventrolateral part of the SCN (VL-SCN) was higher than that of the dorsomedial SCN (DM-SCN) neurons in 14-, 21- and 70-100-day-old rats. Activity of the DM-SCN neurons on day 21 were unaffected by bilateral enucleation on the third day, while activity in the VL-SCN decreased; that of both parts was significantly decreased by a constant light schedule.

Original language	English
Pages (from-to)	29-35
Number of pages	7
Journal	Developmental Brain Research
Volume	13
Issue number	1
DOIs	https://doi.org/10.1016/0165-3806(84)90074-9
Publication status	Published - 1984 Mar
Externally published	Yes

Keywords

lateral hypothalamus
neuronal activity
ontogeny
rat brain slice
suprachiasmatic nucleus
ventromedial hypothalamus

ASJC Scopus subject areas

Developmental Neuroscience
Developmental Biology

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title = "Electrophysiological studies of the development of suprachiasmatic neuronal activity in hypothalamic slice preparations",

abstract = "The rate and pattern of neuronal discharge in the suprachiasmatic nucleus (SCN) during developmental stages were studied and compared with those of the ventromedial (VMH) and the lateral hypothalamus (LHA) using rat hypothalamic slices. The firing rate of the SCN neurons was low on the 7th and 11th days; however, it dramatically increased by the 14th day to reach the adult rate, while firing rates of VMH and LHA neurons increased gradually with age. The discharge rate of neurons in the ventrolateral part of the SCN (VL-SCN) was higher than that of the dorsomedial SCN (DM-SCN) neurons in 14-, 21- and 70-100-day-old rats. Activity of the DM-SCN neurons on day 21 were unaffected by bilateral enucleation on the third day, while activity in the VL-SCN decreased; that of both parts was significantly decreased by a constant light schedule.",

keywords = "lateral hypothalamus, neuronal activity, ontogeny, rat brain slice, suprachiasmatic nucleus, ventromedial hypothalamus",

author = "Shigenobu Shibata and Yutaka Oomura and Liou, {Shyh Yuh} and Showa Ueki",

year = "1984",

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AU - Shibata, Shigenobu

AU - Oomura, Yutaka

AU - Liou, Shyh Yuh

AU - Ueki, Showa

PY - 1984/3

Y1 - 1984/3

N2 - The rate and pattern of neuronal discharge in the suprachiasmatic nucleus (SCN) during developmental stages were studied and compared with those of the ventromedial (VMH) and the lateral hypothalamus (LHA) using rat hypothalamic slices. The firing rate of the SCN neurons was low on the 7th and 11th days; however, it dramatically increased by the 14th day to reach the adult rate, while firing rates of VMH and LHA neurons increased gradually with age. The discharge rate of neurons in the ventrolateral part of the SCN (VL-SCN) was higher than that of the dorsomedial SCN (DM-SCN) neurons in 14-, 21- and 70-100-day-old rats. Activity of the DM-SCN neurons on day 21 were unaffected by bilateral enucleation on the third day, while activity in the VL-SCN decreased; that of both parts was significantly decreased by a constant light schedule.

AB - The rate and pattern of neuronal discharge in the suprachiasmatic nucleus (SCN) during developmental stages were studied and compared with those of the ventromedial (VMH) and the lateral hypothalamus (LHA) using rat hypothalamic slices. The firing rate of the SCN neurons was low on the 7th and 11th days; however, it dramatically increased by the 14th day to reach the adult rate, while firing rates of VMH and LHA neurons increased gradually with age. The discharge rate of neurons in the ventrolateral part of the SCN (VL-SCN) was higher than that of the dorsomedial SCN (DM-SCN) neurons in 14-, 21- and 70-100-day-old rats. Activity of the DM-SCN neurons on day 21 were unaffected by bilateral enucleation on the third day, while activity in the VL-SCN decreased; that of both parts was significantly decreased by a constant light schedule.

KW - lateral hypothalamus

KW - neuronal activity

KW - ontogeny

KW - rat brain slice

KW - suprachiasmatic nucleus

KW - ventromedial hypothalamus

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