Electrophysiological studies of the development of suprachiasmatic neuronal activity in hypothalamic slice preparations

Shigenobu Shibata, Yutaka Oomura, Shyh Yuh Liou, Showa Ueki

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

The rate and pattern of neuronal discharge in the suprachiasmatic nucleus (SCN) during developmental stages were studied and compared with those of the ventromedial (VMH) and the lateral hypothalamus (LHA) using rat hypothalamic slices. The firing rate of the SCN neurons was low on the 7th and 11th days; however, it dramatically increased by the 14th day to reach the adult rate, while firing rates of VMH and LHA neurons increased gradually with age. The discharge rate of neurons in the ventrolateral part of the SCN (VL-SCN) was higher than that of the dorsomedial SCN (DM-SCN) neurons in 14-, 21- and 70-100-day-old rats. Activity of the DM-SCN neurons on day 21 were unaffected by bilateral enucleation on the third day, while activity in the VL-SCN decreased; that of both parts was significantly decreased by a constant light schedule.

Original languageEnglish
Pages (from-to)29-35
Number of pages7
JournalDevelopmental Brain Research
Volume13
Issue number1
DOIs
Publication statusPublished - 1984 Mar
Externally publishedYes

Keywords

  • lateral hypothalamus
  • neuronal activity
  • ontogeny
  • rat brain slice
  • suprachiasmatic nucleus
  • ventromedial hypothalamus

ASJC Scopus subject areas

  • Developmental Neuroscience
  • Developmental Biology

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