Electropolymerization molecularly imprinted polymer (E-MIP) SPR sensing of drug molecules

Pre-polymerization complexed terthiophene and carbazole electroactive monomers

Roderick Pernites, Ramakrishna Ponnapati, Mary Jane Felipe, Rigoberto Advincula

Research output: Contribution to journalArticle

88 Citations (Scopus)

Abstract

A novel chemosensitive ultrathin film with high selectivity was developed for the detection of naproxen, paracetamol, and theophylline using non-covalent electropolymerized molecular imprinted polymers (E-MIP). A series of monofunctional and bifunctional H-bonding terthiophene and carbazole monomers were compared for imprinting these drugs without the use of a separate cross-linker. A key step is the fast and efficient potentiostatic method of washing the template, which facilitated enhanced real-time sensing by surface plasmon resonance (SPR) spectroscopy. Various surface characterizations (contact angle, ellipsometry, XPS, AFM) of the E-MIP film verified the templating and release of the drug from the cross-linked conducting polymer film.

Original languageEnglish
Pages (from-to)2766-2771
Number of pages6
JournalBiosensors and Bioelectronics
Volume26
Issue number5
DOIs
Publication statusPublished - 2011 Jan 15
Externally publishedYes

Fingerprint

Electropolymerization
Surface Plasmon Resonance
Surface plasmon resonance
Polymer films
Polymerization
Polymers
Monomers
Naproxen
Molecules
Ultrathin films
Ellipsometry
Conducting polymers
Theophylline
Acetaminophen
Washing
Pharmaceutical Preparations
Contact angle
X ray photoelectron spectroscopy
Spectroscopy
Spectrum Analysis

Keywords

  • Electropolymerization
  • MIP
  • Naproxen
  • Paracetamol
  • Surface plasmon resonance (SPR) sensing
  • Theophylline

ASJC Scopus subject areas

  • Biotechnology
  • Biophysics
  • Biomedical Engineering
  • Electrochemistry

Cite this

Electropolymerization molecularly imprinted polymer (E-MIP) SPR sensing of drug molecules : Pre-polymerization complexed terthiophene and carbazole electroactive monomers. / Pernites, Roderick; Ponnapati, Ramakrishna; Felipe, Mary Jane; Advincula, Rigoberto.

In: Biosensors and Bioelectronics, Vol. 26, No. 5, 15.01.2011, p. 2766-2771.

Research output: Contribution to journalArticle

Pernites, Roderick ; Ponnapati, Ramakrishna ; Felipe, Mary Jane ; Advincula, Rigoberto. / Electropolymerization molecularly imprinted polymer (E-MIP) SPR sensing of drug molecules : Pre-polymerization complexed terthiophene and carbazole electroactive monomers. In: Biosensors and Bioelectronics. 2011 ; Vol. 26, No. 5. pp. 2766-2771.
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