Electropolymerization molecularly imprinted polymer (E-MIP) SPR sensing of drug molecules: Pre-polymerization complexed terthiophene and carbazole electroactive monomers

Roderick Pernites, Ramakrishna Ponnapati, Mary Jane Felipe, Rigoberto Advincula

Research output: Contribution to journalArticle

95 Citations (Scopus)

Abstract

A novel chemosensitive ultrathin film with high selectivity was developed for the detection of naproxen, paracetamol, and theophylline using non-covalent electropolymerized molecular imprinted polymers (E-MIP). A series of monofunctional and bifunctional H-bonding terthiophene and carbazole monomers were compared for imprinting these drugs without the use of a separate cross-linker. A key step is the fast and efficient potentiostatic method of washing the template, which facilitated enhanced real-time sensing by surface plasmon resonance (SPR) spectroscopy. Various surface characterizations (contact angle, ellipsometry, XPS, AFM) of the E-MIP film verified the templating and release of the drug from the cross-linked conducting polymer film.

Original languageEnglish
Pages (from-to)2766-2771
Number of pages6
JournalBiosensors and Bioelectronics
Volume26
Issue number5
DOIs
Publication statusPublished - 2011 Jan 15
Externally publishedYes

Keywords

  • Electropolymerization
  • MIP
  • Naproxen
  • Paracetamol
  • Surface plasmon resonance (SPR) sensing
  • Theophylline

ASJC Scopus subject areas

  • Biotechnology
  • Biophysics
  • Biomedical Engineering
  • Electrochemistry

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