Electrospinning of plant oil-based, non-isocyanate polyurethanes for biomedical applications

Donald C. Aduba, Keren Zhang, Akanksha Kanitkar, Justin M. Sirrine, Scott S. Verbridge, Timothy Edward Long

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Non-isocyanate polyurethanes (NIPU) have rapidly emerged as a sustainable, less toxic, and environmentally friendly alternative to traditional isocyanate-based thermoplastic polyurethane (TPU) synthesis. TPU is widely used in the medical industry due to its excellent mechanical properties and elasticity. However, little work has been done to synthesize and electrospin NIPU into fibrous mats for biomedical applications. In this work, melt polymerization of a plant oil-based cyclic carbonate monomer with polyether soft segments and various diamines yielded isocyanate-free, segmented poly(amide hydroxyurethane)s (PAHUs). Electrospinning of segmented PAHUs afforded ductile, free-standing fibrous mats with Young's modulus values between 7 and 8 MPa, suitable for tissue scaffold applications. PAHU fiber mats exhibited 3–4 times greater water uptake than the electrospun TPU control, demonstrating potential utility in drug delivery. Fibroblasts adhered to electrospun PAHU fibrous mats with viability values over 90% after 72-h, validating its biocompatibility. The results highlight the high performance and potential of electrospun isocyanate-free polyurethanes mats for biomedical application.

Original languageEnglish
Article number46464
JournalJournal of Applied Polymer Science
Volume135
Issue number29
DOIs
Publication statusPublished - 2018 Aug 5
Externally publishedYes

Fingerprint

Polyurethanes
Plant Oils
Electrospinning
Isocyanates
Thermoplastics
Tissue Scaffolds
Diamines
Polyethers
Poisons
Carbonates
Fibroblasts
Drug delivery
Biocompatibility
Amides
Oils
Elasticity
Monomers
Elastic moduli
Polymerization
Mechanical properties

Keywords

  • biomaterials
  • electrospinning
  • fibers
  • polyurethane

ASJC Scopus subject areas

  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Polymers and Plastics
  • Materials Chemistry

Cite this

Aduba, D. C., Zhang, K., Kanitkar, A., Sirrine, J. M., Verbridge, S. S., & Long, T. E. (2018). Electrospinning of plant oil-based, non-isocyanate polyurethanes for biomedical applications. Journal of Applied Polymer Science, 135(29), [46464]. https://doi.org/10.1002/app.46464

Electrospinning of plant oil-based, non-isocyanate polyurethanes for biomedical applications. / Aduba, Donald C.; Zhang, Keren; Kanitkar, Akanksha; Sirrine, Justin M.; Verbridge, Scott S.; Long, Timothy Edward.

In: Journal of Applied Polymer Science, Vol. 135, No. 29, 46464, 05.08.2018.

Research output: Contribution to journalArticle

Aduba, DC, Zhang, K, Kanitkar, A, Sirrine, JM, Verbridge, SS & Long, TE 2018, 'Electrospinning of plant oil-based, non-isocyanate polyurethanes for biomedical applications', Journal of Applied Polymer Science, vol. 135, no. 29, 46464. https://doi.org/10.1002/app.46464
Aduba, Donald C. ; Zhang, Keren ; Kanitkar, Akanksha ; Sirrine, Justin M. ; Verbridge, Scott S. ; Long, Timothy Edward. / Electrospinning of plant oil-based, non-isocyanate polyurethanes for biomedical applications. In: Journal of Applied Polymer Science. 2018 ; Vol. 135, No. 29.
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