Elevated plasma concentrations of vitamin d-binding protein are associated with lower high-density lipoprotein and higher fat mass index in overweight and obese women

Leila Setayesh; Abbas Amini; Reza Bagheri; Nariman Moradi; Habib Yarizadeh; Omid Asbaghi; Krista Casazza; Mir Saeed Yekaninejad; Alexei Wong; Katsuhiko Suzuki; Khadijeh Mirzaei

doi:10.3390/nu13093223

Elevated plasma concentrations of vitamin d-binding protein are associated with lower high-density lipoprotein and higher fat mass index in overweight and obese women

Leila Setayesh, Abbas Amini, Reza Bagheri, Nariman Moradi, Habib Yarizadeh, Omid Asbaghi, Krista Casazza, Mir Saeed Yekaninejad, Alexei Wong, Katsuhiko Suzuki^*, Khadijeh Mirzaei

^*Corresponding author for this work

School of Sport Sciences

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

(1) Background: Observational studies have established that vitamin D-binding protein (DBP) and 25-hydroxyvitamin D₃ (25(OH)D) concentrations are the major factors affecting the bioavailability of 25(OH)D. It has also been shown that poor 25(OH)D bioavailability elevates the risk of obesity and its related cardio-metabolic disorders. However, the relationship between 25(OH)D and DBP concentrations with cardio-metabolic risk factors in overweight and obese cohorts has not been established. Consequently, we evaluated the association between DBP and 25(OH)D concentrations with lipid profile, blood pressure (BP), and body composition in overweight and obese women. (2) Methods: In this cross-sectional study of 236 overweight and obese women, DBP and 25(OH)D concentrations were measured using an enzyme-linked immunosorbent assay. Body composition was assessed via bioelectrical impedance analysis. Lipid profile and BP were assessed by an auto-analyzer and digital BP monitor, respectively. The associations were examined by multivariate logistic regression. (3) Results: The indicated showed an inverse relationship between DBP and high-density lipoprotein (HDL) (p = 0.010) concentrations (where individuals with higher DBP had lower HDL) which, after adjusting for possible cofounders, remained significant (p = 0.006). Moreover, DBP concentration was positively associated with fat mass index (FMI) after adjustment (p = 0.022). No significant relationships were observed among 25(OH)D and target variables. (4) Conclusions: In conclusion, lower concentrations of HDL and higher values of FMI are associated with higher concentrations of DBP in overweight and obese women. These findings present novel awareness regarding the association of DBP with some metabolic and body composition variables in overweight and obese women. However, a two-way causal relationship between DBP and target variables should be considered.

Original language	English
Article number	3223
Journal	Nutrients
Volume	13
Issue number	9
DOIs	https://doi.org/10.3390/nu13093223
Publication status	Published - 2021 Sept

Keywords

25(OH)D
Adiposity marker
Blood pressure
Cardiovascular risk factors
Lipid profile
Obesity
Vitamin D
Vitamin D binding protein

ASJC Scopus subject areas

Food Science
Nutrition and Dietetics

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10.3390/nu13093223

Cite this

Setayesh, L., Amini, A., Bagheri, R., Moradi, N., Yarizadeh, H., Asbaghi, O., Casazza, K., Yekaninejad, M. S., Wong, A., Suzuki, K., & Mirzaei, K. (2021). Elevated plasma concentrations of vitamin d-binding protein are associated with lower high-density lipoprotein and higher fat mass index in overweight and obese women. Nutrients, 13(9), [3223]. https://doi.org/10.3390/nu13093223

Setayesh, L, Amini, A, Bagheri, R, Moradi, N, Yarizadeh, H, Asbaghi, O, Casazza, K, Yekaninejad, MS, Wong, A, Suzuki, K & Mirzaei, K 2021, 'Elevated plasma concentrations of vitamin d-binding protein are associated with lower high-density lipoprotein and higher fat mass index in overweight and obese women', Nutrients, vol. 13, no. 9, 3223. https://doi.org/10.3390/nu13093223

@article{00996836e0c64d6794b2c450e82260cd,

title = "Elevated plasma concentrations of vitamin d-binding protein are associated with lower high-density lipoprotein and higher fat mass index in overweight and obese women",

abstract = "(1) Background: Observational studies have established that vitamin D-binding protein (DBP) and 25-hydroxyvitamin D3 (25(OH)D) concentrations are the major factors affecting the bioavailability of 25(OH)D. It has also been shown that poor 25(OH)D bioavailability elevates the risk of obesity and its related cardio-metabolic disorders. However, the relationship between 25(OH)D and DBP concentrations with cardio-metabolic risk factors in overweight and obese cohorts has not been established. Consequently, we evaluated the association between DBP and 25(OH)D concentrations with lipid profile, blood pressure (BP), and body composition in overweight and obese women. (2) Methods: In this cross-sectional study of 236 overweight and obese women, DBP and 25(OH)D concentrations were measured using an enzyme-linked immunosorbent assay. Body composition was assessed via bioelectrical impedance analysis. Lipid profile and BP were assessed by an auto-analyzer and digital BP monitor, respectively. The associations were examined by multivariate logistic regression. (3) Results: The indicated showed an inverse relationship between DBP and high-density lipoprotein (HDL) (p = 0.010) concentrations (where individuals with higher DBP had lower HDL) which, after adjusting for possible cofounders, remained significant (p = 0.006). Moreover, DBP concentration was positively associated with fat mass index (FMI) after adjustment (p = 0.022). No significant relationships were observed among 25(OH)D and target variables. (4) Conclusions: In conclusion, lower concentrations of HDL and higher values of FMI are associated with higher concentrations of DBP in overweight and obese women. These findings present novel awareness regarding the association of DBP with some metabolic and body composition variables in overweight and obese women. However, a two-way causal relationship between DBP and target variables should be considered.",

keywords = "25(OH)D, Adiposity marker, Blood pressure, Cardiovascular risk factors, Lipid profile, Obesity, Vitamin D, Vitamin D binding protein",

author = "Leila Setayesh and Abbas Amini and Reza Bagheri and Nariman Moradi and Habib Yarizadeh and Omid Asbaghi and Krista Casazza and Yekaninejad, {Mir Saeed} and Alexei Wong and Katsuhiko Suzuki and Khadijeh Mirzaei",

note = "Funding Information: Funding: This study was partially funded by Tehran University of Medical Science (TUMS) through grant number 97-03-161-40081, and the protocol was approved on 20 February 2019. Publisher Copyright: {\textcopyright} 2021 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2021",

month = sep,

doi = "10.3390/nu13093223",

language = "English",

volume = "13",

journal = "Nutrients",

issn = "2072-6643",

publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

number = "9",

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TY - JOUR

T1 - Elevated plasma concentrations of vitamin d-binding protein are associated with lower high-density lipoprotein and higher fat mass index in overweight and obese women

AU - Setayesh, Leila

AU - Amini, Abbas

AU - Bagheri, Reza

AU - Moradi, Nariman

AU - Yarizadeh, Habib

AU - Asbaghi, Omid

AU - Casazza, Krista

AU - Yekaninejad, Mir Saeed

AU - Wong, Alexei

AU - Suzuki, Katsuhiko

AU - Mirzaei, Khadijeh

N1 - Funding Information: Funding: This study was partially funded by Tehran University of Medical Science (TUMS) through grant number 97-03-161-40081, and the protocol was approved on 20 February 2019. Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland.

PY - 2021/9

Y1 - 2021/9

N2 - (1) Background: Observational studies have established that vitamin D-binding protein (DBP) and 25-hydroxyvitamin D3 (25(OH)D) concentrations are the major factors affecting the bioavailability of 25(OH)D. It has also been shown that poor 25(OH)D bioavailability elevates the risk of obesity and its related cardio-metabolic disorders. However, the relationship between 25(OH)D and DBP concentrations with cardio-metabolic risk factors in overweight and obese cohorts has not been established. Consequently, we evaluated the association between DBP and 25(OH)D concentrations with lipid profile, blood pressure (BP), and body composition in overweight and obese women. (2) Methods: In this cross-sectional study of 236 overweight and obese women, DBP and 25(OH)D concentrations were measured using an enzyme-linked immunosorbent assay. Body composition was assessed via bioelectrical impedance analysis. Lipid profile and BP were assessed by an auto-analyzer and digital BP monitor, respectively. The associations were examined by multivariate logistic regression. (3) Results: The indicated showed an inverse relationship between DBP and high-density lipoprotein (HDL) (p = 0.010) concentrations (where individuals with higher DBP had lower HDL) which, after adjusting for possible cofounders, remained significant (p = 0.006). Moreover, DBP concentration was positively associated with fat mass index (FMI) after adjustment (p = 0.022). No significant relationships were observed among 25(OH)D and target variables. (4) Conclusions: In conclusion, lower concentrations of HDL and higher values of FMI are associated with higher concentrations of DBP in overweight and obese women. These findings present novel awareness regarding the association of DBP with some metabolic and body composition variables in overweight and obese women. However, a two-way causal relationship between DBP and target variables should be considered.

AB - (1) Background: Observational studies have established that vitamin D-binding protein (DBP) and 25-hydroxyvitamin D3 (25(OH)D) concentrations are the major factors affecting the bioavailability of 25(OH)D. It has also been shown that poor 25(OH)D bioavailability elevates the risk of obesity and its related cardio-metabolic disorders. However, the relationship between 25(OH)D and DBP concentrations with cardio-metabolic risk factors in overweight and obese cohorts has not been established. Consequently, we evaluated the association between DBP and 25(OH)D concentrations with lipid profile, blood pressure (BP), and body composition in overweight and obese women. (2) Methods: In this cross-sectional study of 236 overweight and obese women, DBP and 25(OH)D concentrations were measured using an enzyme-linked immunosorbent assay. Body composition was assessed via bioelectrical impedance analysis. Lipid profile and BP were assessed by an auto-analyzer and digital BP monitor, respectively. The associations were examined by multivariate logistic regression. (3) Results: The indicated showed an inverse relationship between DBP and high-density lipoprotein (HDL) (p = 0.010) concentrations (where individuals with higher DBP had lower HDL) which, after adjusting for possible cofounders, remained significant (p = 0.006). Moreover, DBP concentration was positively associated with fat mass index (FMI) after adjustment (p = 0.022). No significant relationships were observed among 25(OH)D and target variables. (4) Conclusions: In conclusion, lower concentrations of HDL and higher values of FMI are associated with higher concentrations of DBP in overweight and obese women. These findings present novel awareness regarding the association of DBP with some metabolic and body composition variables in overweight and obese women. However, a two-way causal relationship between DBP and target variables should be considered.

KW - 25(OH)D

KW - Adiposity marker

KW - Blood pressure

KW - Cardiovascular risk factors

KW - Lipid profile

KW - Obesity

KW - Vitamin D

KW - Vitamin D binding protein

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DO - 10.3390/nu13093223

M3 - Article

C2 - 34579103

AN - SCOPUS:85114879595

SN - 2072-6643

VL - 13

JO - Nutrients

JF - Nutrients

IS - 9

M1 - 3223

ER -

Elevated plasma concentrations of vitamin d-binding protein are associated with lower high-density lipoprotein and higher fat mass index in overweight and obese women

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