Emergence of traveling waves in the zebrafish segmentation clock

Kana Ishimatsu, Atsuko Takamatsu, Hiroyuki Takeda

    Research output: Contribution to journalArticle

    18 Citations (Scopus)

    Abstract

    The spatial and temporal periodicity of somite formation is controlled by the segmentation clock, in which numerous cells cyclically express hairy-related transcriptional repressors with a posterior-to-anterior phase delay, creating 'traveling waves' of her1 expression. In zebrafish, the first traveling wave buds off from the synchronous oscillation zone in the blastoderm margin. Here we show that the emergence of a traveling wave coincides with the anterior expansion of Fgf signaling and that transplanted Fgf8b-soaked beads induce ectopic traveling waves. We thus propose that as development proceeds, the activity of Fgf signaling gradually expands anteriorly, starting from the margin, so that cells initiate her1 oscillation with a posterior-to-anterior phase delay. Furthermore, we suggest that Fgf has an essential role in establishing the period gradient that is required for the her1 spatial oscillation pattern at the emergence of the traveling wave.

    Original languageEnglish
    Pages (from-to)1595-1599
    Number of pages5
    JournalDevelopment
    Volume137
    Issue number10
    DOIs
    Publication statusPublished - 2010 May 15

    Fingerprint

    Zebrafish
    Blastoderm
    Somites
    Periodicity

    Keywords

    • Fgf
    • her1
    • Oscillation
    • Segmentation clock
    • Traveling waves
    • Zebrafish

    ASJC Scopus subject areas

    • Developmental Biology
    • Molecular Biology

    Cite this

    Emergence of traveling waves in the zebrafish segmentation clock. / Ishimatsu, Kana; Takamatsu, Atsuko; Takeda, Hiroyuki.

    In: Development, Vol. 137, No. 10, 15.05.2010, p. 1595-1599.

    Research output: Contribution to journalArticle

    Ishimatsu, Kana ; Takamatsu, Atsuko ; Takeda, Hiroyuki. / Emergence of traveling waves in the zebrafish segmentation clock. In: Development. 2010 ; Vol. 137, No. 10. pp. 1595-1599.
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