Enantioselective construction of quaternary carbon centers by catalytic [2 + 2 + 2] cycloaddition of 1,6-enynes and alkynes

Takanori Shibata, Yoshikazu Arai, Yu Ki Tahara

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Abstract

(Chemical Equation Presented) The enantioselective [2 + 2 + 2] cycloaddition of 1,6-enynes and alkynes using chiral rhodium catalysts gave cycloadducts containing quaternary carbon stereocenters. Both symmetrical and unsymmetrical alkynes and acetylene could be used as coupling partners, and the corresponding bicyclic cyclohexa-1,3-dienes were obtained in good to excellent ee.

Original languageEnglish
Pages (from-to)4955-4957
Number of pages3
JournalOrganic Letters
Volume7
Issue number22
DOIs
Publication statusPublished - 2005 Oct 27

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ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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