Enantioselective construction of quaternary carbon centers by catalytic [2 + 2 + 2] cycloaddition of 1,6-enynes and alkynes

Takanori Shibata, Yoshikazu Arai, Yu Ki Tahara

    Research output: Contribution to journalArticle

    54 Citations (Scopus)

    Abstract

    (Chemical Equation Presented) The enantioselective [2 + 2 + 2] cycloaddition of 1,6-enynes and alkynes using chiral rhodium catalysts gave cycloadducts containing quaternary carbon stereocenters. Both symmetrical and unsymmetrical alkynes and acetylene could be used as coupling partners, and the corresponding bicyclic cyclohexa-1,3-dienes were obtained in good to excellent ee.

    Original languageEnglish
    Pages (from-to)4955-4957
    Number of pages3
    JournalOrganic Letters
    Volume7
    Issue number22
    DOIs
    Publication statusPublished - 2005 Oct 27

    Fingerprint

    Alkynes
    Cycloaddition
    Cycloaddition Reaction
    cycloaddition
    alkynes
    Carbon
    Acetylene
    Rhodium
    carbon
    dienes
    rhodium
    acetylene
    catalysts
    Catalysts

    ASJC Scopus subject areas

    • Molecular Medicine

    Cite this

    Enantioselective construction of quaternary carbon centers by catalytic [2 + 2 + 2] cycloaddition of 1,6-enynes and alkynes. / Shibata, Takanori; Arai, Yoshikazu; Tahara, Yu Ki.

    In: Organic Letters, Vol. 7, No. 22, 27.10.2005, p. 4955-4957.

    Research output: Contribution to journalArticle

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