Abstract
Enantioselective divergent approaches to (-)-platencin and (-)-platensimycin have been developed. A rationally designed chiral synthetic intermediate, possessing a useful α,β-unsaturated sulfone functionality, which served as a masked ketone as well as a good Michael acceptor, was successfully prepared via the highly enantioselective catalytic asymmetric intramolecular cyclopropanation (CAIMCP) developed in our laboratory.
| Original language | English |
|---|---|
| Pages (from-to) | 518-530 |
| Number of pages | 13 |
| Journal | Tetrahedron |
| Volume | 67 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 2011 Jan 14 |
Keywords
- Asymmetric catalysis
- Cyclopropanation
- Divergent approaches
- Enantioselective synthesis
ASJC Scopus subject areas
- Biochemistry
- Drug Discovery
- Organic Chemistry
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Cite this
Hirai, S., & Nakada, M. (2011). Enantioselective divergent approaches to both (-)-platensimycin and (-)-platencin. Tetrahedron, 67(2), 518-530. https://doi.org/10.1016/j.tet.2010.10.076