Abstract
Enantioselective divergent approaches to (-)-platencin and (-)-platensimycin have been developed. A rationally designed chiral synthetic intermediate, possessing a useful α,β-unsaturated sulfone functionality, which served as a masked ketone as well as a good Michael acceptor, was successfully prepared via the highly enantioselective catalytic asymmetric intramolecular cyclopropanation (CAIMCP) developed in our laboratory.
Original language | English |
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Pages (from-to) | 518-530 |
Number of pages | 13 |
Journal | Tetrahedron |
Volume | 67 |
Issue number | 2 |
DOIs | |
Publication status | Published - 2011 Jan 14 |
Keywords
- Asymmetric catalysis
- Cyclopropanation
- Divergent approaches
- Enantioselective synthesis
ASJC Scopus subject areas
- Biochemistry
- Drug Discovery
- Organic Chemistry