TY - JOUR
T1 - Enantioselective divergent approaches to both (-)-platensimycin and (-)-platencin
AU - Hirai, Sho
AU - Nakada, Masahisa
N1 - Funding Information:
This work was financially supported in part by a Waseda University Grant for Special Research Projects, a Grant-in-Aid for Scientific Research on Innovative Areas (No. 21106009 ), and the Global COE program ‘Center for Practical Chemical Wisdom’ by MEXT.
PY - 2011/1/14
Y1 - 2011/1/14
N2 - Enantioselective divergent approaches to (-)-platencin and (-)-platensimycin have been developed. A rationally designed chiral synthetic intermediate, possessing a useful α,β-unsaturated sulfone functionality, which served as a masked ketone as well as a good Michael acceptor, was successfully prepared via the highly enantioselective catalytic asymmetric intramolecular cyclopropanation (CAIMCP) developed in our laboratory.
AB - Enantioselective divergent approaches to (-)-platencin and (-)-platensimycin have been developed. A rationally designed chiral synthetic intermediate, possessing a useful α,β-unsaturated sulfone functionality, which served as a masked ketone as well as a good Michael acceptor, was successfully prepared via the highly enantioselective catalytic asymmetric intramolecular cyclopropanation (CAIMCP) developed in our laboratory.
KW - Asymmetric catalysis
KW - Cyclopropanation
KW - Divergent approaches
KW - Enantioselective synthesis
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U2 - 10.1016/j.tet.2010.10.076
DO - 10.1016/j.tet.2010.10.076
M3 - Article
AN - SCOPUS:78650174098
VL - 67
SP - 518
EP - 530
JO - Tetrahedron
JF - Tetrahedron
SN - 0040-4020
IS - 2
ER -