Enantioselective divergent approaches to both (-)-platensimycin and (-)-platencin

Sho Hirai; Masahisa Nakada

doi:10.1016/j.tet.2010.10.076

Enantioselective divergent approaches to both (-)-platensimycin and (-)-platencin

Sho Hirai, Masahisa Nakada

School of Advanced Science and Engineering

Research output: Contribution to journal › Article

49 Citations (Scopus)

Abstract

Enantioselective divergent approaches to (-)-platencin and (-)-platensimycin have been developed. A rationally designed chiral synthetic intermediate, possessing a useful α,β-unsaturated sulfone functionality, which served as a masked ketone as well as a good Michael acceptor, was successfully prepared via the highly enantioselective catalytic asymmetric intramolecular cyclopropanation (CAIMCP) developed in our laboratory.

Original language	English
Pages (from-to)	518-530
Number of pages	13
Journal	Tetrahedron
Volume	67
Issue number	2
DOIs	https://doi.org/10.1016/j.tet.2010.10.076
Publication status	Published - 2011 Jan 14

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Keywords

Asymmetric catalysis
Cyclopropanation
Divergent approaches
Enantioselective synthesis

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

Cite this

Hirai, S., & Nakada, M. (2011). Enantioselective divergent approaches to both (-)-platensimycin and (-)-platencin. Tetrahedron, 67(2), 518-530. https://doi.org/10.1016/j.tet.2010.10.076

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10.1016/j.tet.2010.10.076