Enantioselective divergent approaches to both (-)-platensimycin and (-)-platencin

Sho Hirai, Masahisa Nakada

    Research output: Contribution to journal › Article

    49 Citations (Scopus)

    Abstract

    Enantioselective divergent approaches to (-)-platencin and (-)-platensimycin have been developed. A rationally designed chiral synthetic intermediate, possessing a useful α,β-unsaturated sulfone functionality, which served as a masked ketone as well as a good Michael acceptor, was successfully prepared via the highly enantioselective catalytic asymmetric intramolecular cyclopropanation (CAIMCP) developed in our laboratory.

    Original languageEnglish
    Pages (from-to)518-530
    Number of pages13
    JournalTetrahedron
    Volume67
    Issue number2
    DOIs
    Publication statusPublished - 2011 Jan 14

    Fingerprint

    Sulfones
    Ketones
    platensimycin
    platencin

    Keywords

    • Asymmetric catalysis
    • Cyclopropanation
    • Divergent approaches
    • Enantioselective synthesis

    ASJC Scopus subject areas

    • Biochemistry
    • Organic Chemistry
    • Drug Discovery

    Cite this

    Enantioselective divergent approaches to both (-)-platensimycin and (-)-platencin. / Hirai, Sho; Nakada, Masahisa.

    In: Tetrahedron, Vol. 67, No. 2, 14.01.2011, p. 518-530.

    Research output: Contribution to journal › Article

    Hirai, S & Nakada, M 2011, 'Enantioselective divergent approaches to both (-)-platensimycin and (-)-platencin', Tetrahedron, vol. 67, no. 2, pp. 518-530. https://doi.org/10.1016/j.tet.2010.10.076
    Hirai S, Nakada M. Enantioselective divergent approaches to both (-)-platensimycin and (-)-platencin. Tetrahedron. 2011 Jan 14;67(2):518-530. https://doi.org/10.1016/j.tet.2010.10.076
    Hirai, Sho ; Nakada, Masahisa. / Enantioselective divergent approaches to both (-)-platensimycin and (-)-platencin. In: Tetrahedron. 2011 ; Vol. 67, No. 2. pp. 518-530.
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