Enantioselective hydrolysis of dialkyl 3-monosubstituted glutarates with pig liver esterase: Structure-optical purity relationships

Masahisa Nakada, Susumu Kobayashi, Masaji Ohno, Shigeo Iwasaki, Shigenobu Okuda

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Dialkyl 3-monosubstituted glutarates are subjected to hydrolysis with pig liver esterase to afford the corresponding chiral half-esters. Synthetically useful half-esters of higher optical purity are obtained from the prochiral substrates of more hydrophobic nature.

Original languageEnglish
Pages (from-to)3951-3954
Number of pages4
JournalTetrahedron Letters
Volume29
Issue number32
DOIs
Publication statusPublished - 1988
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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