Dialkyl 3-monosubstituted glutarates are subjected to hydrolysis with pig liver esterase to afford the corresponding chiral half-esters. Synthetically useful half-esters of higher optical purity are obtained from the prochiral substrates of more hydrophobic nature.
|Number of pages||4|
|Publication status||Published - 1988|
ASJC Scopus subject areas
- Drug Discovery
- Organic Chemistry