Enantioselective hydrolysis of dialkyl 3-monosubstituted glutarates with pig liver esterase

Structure-optical purity relationships

Masahisa Nakada, Susumu Kobayashi, Masaji Ohno, Shigeo Iwasaki, Shigenobu Okuda

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Dialkyl 3-monosubstituted glutarates are subjected to hydrolysis with pig liver esterase to afford the corresponding chiral half-esters. Synthetically useful half-esters of higher optical purity are obtained from the prochiral substrates of more hydrophobic nature.

Original languageEnglish
Pages (from-to)3951-3954
Number of pages4
JournalTetrahedron Letters
Volume29
Issue number32
DOIs
Publication statusPublished - 1988
Externally publishedYes

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Glutarates
Esterases
Liver
Hydrolysis
Esters
Swine
Substrates

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Cite this

Enantioselective hydrolysis of dialkyl 3-monosubstituted glutarates with pig liver esterase : Structure-optical purity relationships. / Nakada, Masahisa; Kobayashi, Susumu; Ohno, Masaji; Iwasaki, Shigeo; Okuda, Shigenobu.

In: Tetrahedron Letters, Vol. 29, No. 32, 1988, p. 3951-3954.

Research output: Contribution to journalArticle

Nakada, Masahisa ; Kobayashi, Susumu ; Ohno, Masaji ; Iwasaki, Shigeo ; Okuda, Shigenobu. / Enantioselective hydrolysis of dialkyl 3-monosubstituted glutarates with pig liver esterase : Structure-optical purity relationships. In: Tetrahedron Letters. 1988 ; Vol. 29, No. 32. pp. 3951-3954.
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