Enantioselective hydrolysis of dialkyl 3-monosubstituted glutarates with pig liver esterase: Structure-optical purity relationships

Masahisa Nakada; Susumu Kobayashi; Masaji Ohno; Shigeo Iwasaki; Shigenobu Okuda

doi:10.1016/S0040-4039(00)80391-3

Enantioselective hydrolysis of dialkyl 3-monosubstituted glutarates with pig liver esterase: Structure-optical purity relationships

Masahisa Nakada^*, Susumu Kobayashi, Masaji Ohno, Shigeo Iwasaki, Shigenobu Okuda

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

32 Citations (Scopus)

Abstract

Dialkyl 3-monosubstituted glutarates are subjected to hydrolysis with pig liver esterase to afford the corresponding chiral half-esters. Synthetically useful half-esters of higher optical purity are obtained from the prochiral substrates of more hydrophobic nature.

Original language	English
Pages (from-to)	3951-3954
Number of pages	4
Journal	Tetrahedron Letters
Volume	29
Issue number	32
DOIs	https://doi.org/10.1016/S0040-4039(00)80391-3
Publication status	Published - 1988
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/S0040-4039(00)80391-3

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title = "Enantioselective hydrolysis of dialkyl 3-monosubstituted glutarates with pig liver esterase: Structure-optical purity relationships",

abstract = "Dialkyl 3-monosubstituted glutarates are subjected to hydrolysis with pig liver esterase to afford the corresponding chiral half-esters. Synthetically useful half-esters of higher optical purity are obtained from the prochiral substrates of more hydrophobic nature.",

author = "Masahisa Nakada and Susumu Kobayashi and Masaji Ohno and Shigeo Iwasaki and Shigenobu Okuda",

year = "1988",

doi = "10.1016/S0040-4039(00)80391-3",

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journal = "Tetrahedron Letters",

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T1 - Enantioselective hydrolysis of dialkyl 3-monosubstituted glutarates with pig liver esterase

T2 - Structure-optical purity relationships

AU - Nakada, Masahisa

AU - Kobayashi, Susumu

AU - Ohno, Masaji

AU - Iwasaki, Shigeo

AU - Okuda, Shigenobu

PY - 1988

Y1 - 1988

N2 - Dialkyl 3-monosubstituted glutarates are subjected to hydrolysis with pig liver esterase to afford the corresponding chiral half-esters. Synthetically useful half-esters of higher optical purity are obtained from the prochiral substrates of more hydrophobic nature.

AB - Dialkyl 3-monosubstituted glutarates are subjected to hydrolysis with pig liver esterase to afford the corresponding chiral half-esters. Synthetically useful half-esters of higher optical purity are obtained from the prochiral substrates of more hydrophobic nature.

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U2 - 10.1016/S0040-4039(00)80391-3

DO - 10.1016/S0040-4039(00)80391-3

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AN - SCOPUS:0003413818

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JO - Tetrahedron Letters

JF - Tetrahedron Letters

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Enantioselective hydrolysis of dialkyl 3-monosubstituted glutarates with pig liver esterase: Structure-optical purity relationships

Abstract

ASJC Scopus subject areas

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