Enantioselective synthesis of chiral tripodal cage compounds by [2 + 2 + 2] cycloaddition of branched triynes

Takanori Shibata, Toshifumi Uchiyama, Kohei Endo

    Research output: Contribution to journalArticle

    43 Citations (Scopus)


    Cyclotrimerization of triynes branched by a nitrogen atom of 2-aminophenol yielded planar-chiral tripodal cage compounds. When a cationic Rh-Me-DUPHOS catalyst was used, the cycloadducts were obtained in high yield and excellent ee, and a macrocyclic compound with a [15]cyclophane system was also obtained. This method can be further applied to the synthesis of a triarmed pyridinophane by the intramolecular reaction of a diyne-nitrile.

    Original languageEnglish
    Pages (from-to)3906-3908
    Number of pages3
    JournalOrganic Letters
    Issue number17
    Publication statusPublished - 2009 Sep 3


    ASJC Scopus subject areas

    • Organic Chemistry
    • Physical and Theoretical Chemistry
    • Biochemistry

    Cite this