Enantioselective total synthesis of (+)-digitoxigenin

Masahiro Honma, Masahisa Nakada

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Abstract

An enantioselective total synthesis of (+)-digitoxigenin is described. This total synthesis is accomplished in a convergent manner using two chiral fragments prepared via the catalytic asymmetric intramolecular cyclopropanation and baker's yeast mediated reduction developed by us, respectively. This convergent synthesis would be useful for preparing some new derivatives of digitoxigenin for SAR studies and could be applied for the total synthesis of other cardenolides left unprepared.

Original languageEnglish
Pages (from-to)1541-1544
Number of pages4
JournalTetrahedron Letters
Volume48
Issue number9
DOIs
Publication statusPublished - 2007 Feb 26

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ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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