Enantioselective total synthesis of (-)-erinacine B

Hideaki Watanabe, Masashi Takano, Akinori Umino, Toshiya Ito, Hiroyuki Ishikawa, Masahisa Nakada

Research output: Contribution to journalArticle

40 Citations (Scopus)


(Chemical Equation Presented) The first enantioselective total synthesis of (-)-erinacine B has been achieved. Our approach features convergent construction of the 5-6-7 tricyclic cyathane core system via chiral building blocks prepared using asymmetric catalysis developed by us and highly stereoselective construction of all stereogenic centers in the aglycon.

Original languageEnglish
Pages (from-to)359-362
Number of pages4
JournalOrganic Letters
Issue number2
Publication statusPublished - 2007 Jan 18

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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    Watanabe, H., Takano, M., Umino, A., Ito, T., Ishikawa, H., & Nakada, M. (2007). Enantioselective total synthesis of (-)-erinacine B. Organic Letters, 9(2), 359-362. https://doi.org/10.1021/ol0628816