Encoding and decoding time in neural development

Kenichi Toma, Tien Cheng Wang, Carina Hanashima

Research output: Contribution to journalReview article

8 Citations (Scopus)

Abstract

The development of a multicellular organism involves time-dependent changes in molecular and cellular states; therefore 'time' is an indispensable mathematical parameter of ontogenesis. Regardless of their inextricable relationship, there is a limited number of events for which the output of developmental phenomena primarily uses temporal cues that are generated through multilevel interactions between molecules, cells, and tissues. In this review, we focus on neural stem cells, which serve as a faithful decoder of temporal cues to transmit biological information and generate specific output in the developing nervous system. We further explore the identity of the temporal information that is encoded in neural development, and how this information is decoded into various cellular fate decisions. This review focus on neural stem cells as a decoder of temporal cues to transmit biological information and generate particular output in the developing nervous system.

Original languageEnglish
Pages (from-to)59-72
Number of pages14
JournalDevelopment Growth and Differentiation
Volume58
Issue number1
DOIs
Publication statusPublished - 2016 Jan 1
Externally publishedYes

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Cues
Neural Stem Cells
Nervous System

Keywords

  • Cell cycle
  • Neural stem cell
  • Temporal code
  • Timing
  • Transcriptional network

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

Cite this

Encoding and decoding time in neural development. / Toma, Kenichi; Wang, Tien Cheng; Hanashima, Carina.

In: Development Growth and Differentiation, Vol. 58, No. 1, 01.01.2016, p. 59-72.

Research output: Contribution to journalReview article

Toma, Kenichi ; Wang, Tien Cheng ; Hanashima, Carina. / Encoding and decoding time in neural development. In: Development Growth and Differentiation. 2016 ; Vol. 58, No. 1. pp. 59-72.
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