End-Sealed High Aspect Ratio Hollow Nanotubes Encapsulating an Anticancer Drug: Torpedo-Shaped Peptidic Nanocapsules

Motoki Ueda, Siyoong Seo, Baiju G. Nair, Stefan Müller, Eiki Takahashi, Takashi Arai, Tomonori Iyoda, Shin Ichiro Fujii, Satoshi Tsuneda, Yoshihiro Ito

Research output: Contribution to journalArticle

Abstract

Nanomaterial morphology is important for the targeted delivery of drugs to tissues as well as subsequent cellular uptake. Hollow nanotubes composed of peptides, with a diameter of 80 nm and various lengths (100, 200, 300, 600 nm), were successfully capped and sealed with a peptide hemisphere to encapsulate the anticancer drug, cisplatin. The torpedo-shaped nanocapsules with an aspect ratio (length/diameter) of 2.4 showed more rapid cellular uptake and accumulation at the tumor site compared with spherical analogues. Successful delivery of cisplatin to tumors was achieved in a mouse model and tumor growth was efficiently suppressed.

LanguageEnglish
JournalACS Nano
DOIs
Publication statusAccepted/In press - 2019 Jan 1

Fingerprint

torpedoes
Nanocapsules
encapsulating
high aspect ratio
Nanotubes
Aspect ratio
Tumors
hollow
nanotubes
drugs
tumors
Peptides
Cisplatin
Peptide Nanotubes
peptides
delivery
Pharmaceutical Preparations
hemispheres
Nanostructured materials
mice

Keywords

  • aspect ratio
  • cellular uptake
  • drug delivery carrier
  • morphology
  • peptide nanocapsule

ASJC Scopus subject areas

  • Materials Science(all)
  • Engineering(all)
  • Physics and Astronomy(all)

Cite this

End-Sealed High Aspect Ratio Hollow Nanotubes Encapsulating an Anticancer Drug : Torpedo-Shaped Peptidic Nanocapsules. / Ueda, Motoki; Seo, Siyoong; Nair, Baiju G.; Müller, Stefan; Takahashi, Eiki; Arai, Takashi; Iyoda, Tomonori; Fujii, Shin Ichiro; Tsuneda, Satoshi; Ito, Yoshihiro.

In: ACS Nano, 01.01.2019.

Research output: Contribution to journalArticle

Ueda, Motoki ; Seo, Siyoong ; Nair, Baiju G. ; Müller, Stefan ; Takahashi, Eiki ; Arai, Takashi ; Iyoda, Tomonori ; Fujii, Shin Ichiro ; Tsuneda, Satoshi ; Ito, Yoshihiro. / End-Sealed High Aspect Ratio Hollow Nanotubes Encapsulating an Anticancer Drug : Torpedo-Shaped Peptidic Nanocapsules. In: ACS Nano. 2019.
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