End-Sealed High Aspect Ratio Hollow Nanotubes Encapsulating an Anticancer Drug: Torpedo-Shaped Peptidic Nanocapsules

Motoki Ueda, Siyoong Seo, Baiju G. Nair, Stefan Müller, Eiki Takahashi, Takashi Arai, Tomonori Iyoda, Shin Ichiro Fujii, Satoshi Tsuneda, Yoshihiro Ito

    Research output: Contribution to journalArticle

    1 Citation (Scopus)

    Abstract

    Nanomaterial morphology is important for the targeted delivery of drugs to tissues as well as subsequent cellular uptake. Hollow nanotubes composed of peptides, with a diameter of 80 nm and various lengths (100, 200, 300, 600 nm), were successfully capped and sealed with a peptide hemisphere to encapsulate the anticancer drug, cisplatin. The torpedo-shaped nanocapsules with an aspect ratio (length/diameter) of 2.4 showed more rapid cellular uptake and accumulation at the tumor site compared with spherical analogues. Successful delivery of cisplatin to tumors was achieved in a mouse model and tumor growth was efficiently suppressed.

    Original languageEnglish
    JournalACS Nano
    DOIs
    Publication statusAccepted/In press - 2019 Jan 1

    Fingerprint

    torpedoes
    Nanocapsules
    encapsulating
    high aspect ratio
    Nanotubes
    Aspect ratio
    Tumors
    hollow
    nanotubes
    drugs
    tumors
    Peptides
    Cisplatin
    Peptide Nanotubes
    peptides
    delivery
    Pharmaceutical Preparations
    hemispheres
    Nanostructured materials
    mice

    Keywords

    • aspect ratio
    • cellular uptake
    • drug delivery carrier
    • morphology
    • peptide nanocapsule

    ASJC Scopus subject areas

    • Materials Science(all)
    • Engineering(all)
    • Physics and Astronomy(all)

    Cite this

    End-Sealed High Aspect Ratio Hollow Nanotubes Encapsulating an Anticancer Drug : Torpedo-Shaped Peptidic Nanocapsules. / Ueda, Motoki; Seo, Siyoong; Nair, Baiju G.; Müller, Stefan; Takahashi, Eiki; Arai, Takashi; Iyoda, Tomonori; Fujii, Shin Ichiro; Tsuneda, Satoshi; Ito, Yoshihiro.

    In: ACS Nano, 01.01.2019.

    Research output: Contribution to journalArticle

    Ueda, Motoki ; Seo, Siyoong ; Nair, Baiju G. ; Müller, Stefan ; Takahashi, Eiki ; Arai, Takashi ; Iyoda, Tomonori ; Fujii, Shin Ichiro ; Tsuneda, Satoshi ; Ito, Yoshihiro. / End-Sealed High Aspect Ratio Hollow Nanotubes Encapsulating an Anticancer Drug : Torpedo-Shaped Peptidic Nanocapsules. In: ACS Nano. 2019.
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    AU - Nair, Baiju G.

    AU - Müller, Stefan

    AU - Takahashi, Eiki

    AU - Arai, Takashi

    AU - Iyoda, Tomonori

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