End-Sealed High Aspect Ratio Hollow Nanotubes Encapsulating an Anticancer Drug: Torpedo-Shaped Peptidic Nanocapsules

Motoki Ueda, Siyoong Seo, Baiju G. Nair, Stefan Müller, Eiki Takahashi, Takashi Arai, Tomonori Iyoda, Shin Ichiro Fujii, Satoshi Tsuneda, Yoshihiro Ito

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    3 Citations (Scopus)

    Abstract

    Nanomaterial morphology is important for the targeted delivery of drugs to tissues as well as subsequent cellular uptake. Hollow nanotubes composed of peptides, with a diameter of 80 nm and various lengths (100, 200, 300, 600 nm), were successfully capped and sealed with a peptide hemisphere to encapsulate the anticancer drug, cisplatin. The torpedo-shaped nanocapsules with an aspect ratio (length/diameter) of 2.4 showed more rapid cellular uptake and accumulation at the tumor site compared with spherical analogues. Successful delivery of cisplatin to tumors was achieved in a mouse model and tumor growth was efficiently suppressed.

    Original languageEnglish
    JournalACS Nano
    DOIs
    Publication statusAccepted/In press - 2019 Jan 1

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    Keywords

    • aspect ratio
    • cellular uptake
    • drug delivery carrier
    • morphology
    • peptide nanocapsule

    ASJC Scopus subject areas

    • Materials Science(all)
    • Engineering(all)
    • Physics and Astronomy(all)

    Cite this

    Ueda, M., Seo, S., Nair, B. G., Müller, S., Takahashi, E., Arai, T., Iyoda, T., Fujii, S. I., Tsuneda, S., & Ito, Y. (Accepted/In press). End-Sealed High Aspect Ratio Hollow Nanotubes Encapsulating an Anticancer Drug: Torpedo-Shaped Peptidic Nanocapsules. ACS Nano. https://doi.org/10.1021/acsnano.8b06189