Endorphins and pain relief. Further observations on electrical stimulation of the lateral part of the periaqueductal gray matter during rostral mesencephalic reticulotomy for pain relief

K. Amano, T. Tanikawa, H. Kawamura, Hiroshi Iseki, M. Notani, H. Kawabatake, T. Shiwaku, T. Suda, H. Demura, K. Kitamura

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

The authors postulate that the elevation of endorphin on stimulation of the periaqueductal gray matter may be related to psychological aspects of pain perception in relation to emotional stress or alterations of autonomic function, elevation of endorphin being a self-defense phenomenon against noxious impulses. Since all of the 14 patients failed to have pain relief by the electrical stimulation of the periaqueductal gray matter, they had rostral mesencephalic reticulotomy afterwards, in which 9 patients obtained satisfactory pain relief. Rostral mesencephlic reticulotomy is based on the concept that nociception is mediated via the medial part of the reticular formation rather than the lateral spinothalamic tract at midbrain level, being totally different from the procedure of pain relief by mesencephalotomy.

Original languageEnglish
Pages (from-to)123-135
Number of pages13
JournalApplied Neurophysiology
Volume45
Issue number1-2
Publication statusPublished - 1982
Externally publishedYes

Fingerprint

Endorphins
Periaqueductal Gray
Electric Stimulation
Pain
Spinothalamic Tracts
Pain Perception
Reticular Formation
Nociception
Mesencephalon
Psychological Stress
Psychology

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Endorphins and pain relief. Further observations on electrical stimulation of the lateral part of the periaqueductal gray matter during rostral mesencephalic reticulotomy for pain relief. / Amano, K.; Tanikawa, T.; Kawamura, H.; Iseki, Hiroshi; Notani, M.; Kawabatake, H.; Shiwaku, T.; Suda, T.; Demura, H.; Kitamura, K.

In: Applied Neurophysiology, Vol. 45, No. 1-2, 1982, p. 123-135.

Research output: Contribution to journalArticle

Amano, K, Tanikawa, T, Kawamura, H, Iseki, H, Notani, M, Kawabatake, H, Shiwaku, T, Suda, T, Demura, H & Kitamura, K 1982, 'Endorphins and pain relief. Further observations on electrical stimulation of the lateral part of the periaqueductal gray matter during rostral mesencephalic reticulotomy for pain relief', Applied Neurophysiology, vol. 45, no. 1-2, pp. 123-135.
Amano, K. ; Tanikawa, T. ; Kawamura, H. ; Iseki, Hiroshi ; Notani, M. ; Kawabatake, H. ; Shiwaku, T. ; Suda, T. ; Demura, H. ; Kitamura, K. / Endorphins and pain relief. Further observations on electrical stimulation of the lateral part of the periaqueductal gray matter during rostral mesencephalic reticulotomy for pain relief. In: Applied Neurophysiology. 1982 ; Vol. 45, No. 1-2. pp. 123-135.
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