Endosymbiosis as a compact ecosystem with material cycling

Parasitism or mutualism?

Shin Fukui, Takema Fukatsu, Takashi Ikegami, Masakazu Shimada

Research output: Contribution to journalArticle

Abstract

To discover the evolutionary logic of intracellular endosymbiosis, we investigated a theoretical model (simultaneous ordinary differential equations) of a material-cycling system inside a host cell. In the model, we introduced a recently developed cell biology concept called "autophagy", which is a decomposing-recycle process of self-compiled materials found universally among eukaryote cells. Our model is based on traditional simultaneous ODE for natural ecosystems that involve producing, grazing, and decomposing processes in material cycling. In the basic intracellular metabolic system, several enzymes regulate metabolism by synthesizing and converting metabolites into biomolecules that are precursors for enzymes involved in the producing process. Symbionts are involved in grazing processes and autophagosomes that degrade materials are involved in decomposing recycles. We compared and analyzed the local stability of ODE systems in three cases: (1) the independent, free-living cell (the basal state of a cell), (2) the case where symbionts invade and exploit macrobiomaterials as parasites inside a host cell, and (3) the combination where symbionts assist the host's metabolism. We conclude that: (i) as consumers, symbionts are required to have a growth rate that is higher than the rate of autophagosome decomposition, (ii) the host cell with a biomass larger than the threshold size would realize the mutualistic relationship with its symbiont, and (iii) this partnership accelerates the biomaterial turnover flow on the basis of biomaterials.

Original languageEnglish
Pages (from-to)746-754
Number of pages9
JournalJournal of Theoretical Biology
Volume246
Issue number4
DOIs
Publication statusPublished - 2007 Jun 21
Externally publishedYes

Fingerprint

Mutualism
Symbiosis
mutualism
Cycling
Ecosystem
Ecosystems
symbiosis
parasitism
symbionts
ecosystems
Cell
Biocompatible Materials
Metabolism
Biomaterials
biocompatible materials
Enzymes
Cytology
cells
Enzyme Precursors
Biomolecules

Keywords

  • Autophagy
  • Decomposing process
  • Evolution
  • Metabolic system
  • Turnover flow

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)

Cite this

Endosymbiosis as a compact ecosystem with material cycling : Parasitism or mutualism? / Fukui, Shin; Fukatsu, Takema; Ikegami, Takashi; Shimada, Masakazu.

In: Journal of Theoretical Biology, Vol. 246, No. 4, 21.06.2007, p. 746-754.

Research output: Contribution to journalArticle

Fukui, Shin ; Fukatsu, Takema ; Ikegami, Takashi ; Shimada, Masakazu. / Endosymbiosis as a compact ecosystem with material cycling : Parasitism or mutualism?. In: Journal of Theoretical Biology. 2007 ; Vol. 246, No. 4. pp. 746-754.
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