Endurance training regulates expression of some angiogenesis-related genes in cardiac tissue of experimentally induced diabetic rats

Mojdeh Khajehlandi, Lotfali Bolboli, Marefat Siahkuhian, Mohammad Rami, Mohammadreza Tabandeh, Kayvan Khoramipour, Katsuhiko Suzuki

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Exercise can ameliorate cardiovascular dysfunctions in the diabetes condition, but its pre-cise molecular mechanisms have not been entirely understood. The aim of the present study was to determine the impact of endurance training on expression of angiogenesis-related genes in cardiac tissue of diabetic rats. Thirty adults male Wistar rats were randomly divided into three groups (N = 10) including diabetic training (DT), sedentary diabetes (SD), and sedentary healthy (SH), in which diabetes was induced by a single dose of streptozotocin (50 mg/kg). Endurance training (ET) with moderate-intensity was performed on a motorized treadmill for six weeks. Training duration and treadmill speed were increased during five weeks, but they were kept constant at the final week, and slope was zero at all stages. Real-time polymerase chain reaction (RT-PCR) analysis was used to measure the expression of myocyte enhancer factor-2C (MEF2C), histone deacetylase-4 (HDAC4) and Calmodulin-dependent protein kinase II (CaMKII) in cardiac tissues of the rats. Our results demonstrated that six weeks of ET increased gene expression of MEF2C significantly (p < 0.05), and caused a significant reduction in HDAC4 and CaMKII gene expression in the DT rats compared to the SD rats (p < 0.05). We concluded that moderate-intensity ET could play a critical role in amelio-rating cardiovascular dysfunction in a diabetes condition by regulating the expression of some an-giogenesis-related genes in cardiac tissues.

Original languageEnglish
Article number498
JournalBiomolecules
Volume11
Issue number4
DOIs
Publication statusPublished - 2021 Apr

Keywords

  • Angiogenesis
  • Cardiac tissue
  • Endurance training

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

Fingerprint

Dive into the research topics of 'Endurance training regulates expression of some angiogenesis-related genes in cardiac tissue of experimentally induced diabetic rats'. Together they form a unique fingerprint.

Cite this