Engineering analysis of the effects of bulging sinuses in a newly designed pediatric pulmonary heart valve on hemodynamic function

Ichiro Suzuki, Yasuyuki Shiraishi, Shota Yabe, Yusuke Tsuboko, Telma Keiko Sugai, Ken Matsue, Takeyoshi Kameyama, Yoshifumi Saijo, Takashi Tanaka, Yoshihiro Okamoto, Zhonggang Feng, Takako Miyazaki, Masaaki Yamagishi, Makoto Yoshizawa, Mitsuo Umezu, Tomoyuki Yambe

    Research output: Contribution to journalArticle

    18 Citations (Scopus)

    Abstract

    The purpose of this study was to examine the hemodynamic characteristics of expanded polytetrafluoroethylene (ePTFE) pulmonary valves with bulging sinuses quantitatively in a pediatric pulmonary mechanical circulatory system designed by us, in order to propose the optimal design for clinical applications. In this study, we developed a pediatric pulmonary mock circulation system, which consisted of a pneumatic right ventricular model, a pulmonary heart valve chamber, and a pulmonary elastic compliance tubing with resistive units. The hemodynamic characteristics of four different types of ePTFE valves and a monoleaflet mechanical heart valve were examined. Relationships between the leaflet movements and fluid characteristics were evaluated based on engineering analyses using echocardiography and a high-speed video camera under the pediatric circulatory conditions of the mock system. We successfully performed hemodynamic simulations in our pediatric pulmonary circulatory system that could be useful for quantitatively evaluating the pediatric heart valves. In the simulation study, the ePTFE valve with bulging sinuses exhibited a large eddy in the vicinity of the leaflets, whereas the straight tubing exhibited turbulent flow. The Reynolds number obtained in the valve with bulging sinuses was calculated to be 1667, which was smaller than that in the straight tubing (R e = 2454). The hemodynamic characteristics of ePTFE pediatric pulmonary heart valves were examined in our mock circulatory system. The presence of the bulging sinuses in the pulmonary heart valve decreased the hydrodynamic energy loss and increased the systolic opening area. Based on an in vitro experiment, we were able to propose an optimal selection of pulmonary valve design parameters that could yield a more sophisticated pediatric ePTFE valve shape.

    Original languageEnglish
    Pages (from-to)49-56
    Number of pages8
    JournalJournal of Artificial Organs
    Volume15
    Issue number1
    DOIs
    Publication statusPublished - 2012 Mar

    Fingerprint

    Pulmonary Valve
    Pediatrics
    Heart Valves
    Hemodynamics
    Polytetrafluoroethylene
    Polytetrafluoroethylenes
    Tubing
    Cardiovascular System
    Lung Compliance
    Echocardiography
    Lung
    Pulmonary Circulation
    High speed cameras
    Video cameras
    Hydrodynamics
    Pneumatics
    Turbulent flow
    Energy dissipation
    Reynolds number
    Fluids

    Keywords

    • Bulging sinus
    • ePTFE
    • Hemodynamic examination
    • Pediatric pulmonary heart valve

    ASJC Scopus subject areas

    • Biomaterials
    • Biomedical Engineering
    • Cardiology and Cardiovascular Medicine
    • Medicine (miscellaneous)

    Cite this

    Engineering analysis of the effects of bulging sinuses in a newly designed pediatric pulmonary heart valve on hemodynamic function. / Suzuki, Ichiro; Shiraishi, Yasuyuki; Yabe, Shota; Tsuboko, Yusuke; Sugai, Telma Keiko; Matsue, Ken; Kameyama, Takeyoshi; Saijo, Yoshifumi; Tanaka, Takashi; Okamoto, Yoshihiro; Feng, Zhonggang; Miyazaki, Takako; Yamagishi, Masaaki; Yoshizawa, Makoto; Umezu, Mitsuo; Yambe, Tomoyuki.

    In: Journal of Artificial Organs, Vol. 15, No. 1, 03.2012, p. 49-56.

    Research output: Contribution to journalArticle

    Suzuki, I, Shiraishi, Y, Yabe, S, Tsuboko, Y, Sugai, TK, Matsue, K, Kameyama, T, Saijo, Y, Tanaka, T, Okamoto, Y, Feng, Z, Miyazaki, T, Yamagishi, M, Yoshizawa, M, Umezu, M & Yambe, T 2012, 'Engineering analysis of the effects of bulging sinuses in a newly designed pediatric pulmonary heart valve on hemodynamic function', Journal of Artificial Organs, vol. 15, no. 1, pp. 49-56. https://doi.org/10.1007/s10047-011-0609-1
    Suzuki, Ichiro ; Shiraishi, Yasuyuki ; Yabe, Shota ; Tsuboko, Yusuke ; Sugai, Telma Keiko ; Matsue, Ken ; Kameyama, Takeyoshi ; Saijo, Yoshifumi ; Tanaka, Takashi ; Okamoto, Yoshihiro ; Feng, Zhonggang ; Miyazaki, Takako ; Yamagishi, Masaaki ; Yoshizawa, Makoto ; Umezu, Mitsuo ; Yambe, Tomoyuki. / Engineering analysis of the effects of bulging sinuses in a newly designed pediatric pulmonary heart valve on hemodynamic function. In: Journal of Artificial Organs. 2012 ; Vol. 15, No. 1. pp. 49-56.
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