Enhancement of dopamine release from the striatum through metabotropic glutamate receptor activation in methamphetamine sensitized rats

Ikumi Arai, Takao Shimazoe, Shigenobu Shibata, Hirotaka Inoue, Akiko Yoshimatsu, Shigenori Watanabe

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

An intracerebral microdialysis technique was applied to study the effect of metabotropic glutamate receptor (mGluR) agonist on dopamine release in the striatum of methamphetamine (MAP)-sensitized rats. Rats were treated with MAP (1 mg/kg, i.p.) once daily for 6 consecutive days, followed by it 6-day withdrawal. Perfusion of 0.1 mM (1S,3R)-1-aminocyclopentane-trans-1,3-dicarboxylic acid through a microdialysis probe placed in the striatum enhanced the extracellular dopamine level, and induced stereotyped behavior in MAP-sensitized rats. The enhancement of dopamine release and the stereotyped behavior were attenuated by co-perfusion of 0.4 mM RS-α-methyl-4-carboxyphenyl-glycine, a mGluR antagonist. The present results suggest that mGluRs may be involved in the expression of MAP-induced sensitization.

Original languageEnglish
Pages (from-to)277-280
Number of pages4
JournalBrain Research
Volume729
Issue number2
DOIs
Publication statusPublished - 1996 Aug 12

Keywords

  • Dopamine release
  • Expression
  • Metabotropic glutamate receptor
  • Methamphetamine sensitization
  • Microdialysis
  • Striatum

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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