Enhancement of dopamine release from the striatum through metabotropic glutamate receptor activation in methamphetamine sensitized rats

Ikumi Arai; Takao Shimazoe; Shigenobu Shibata; Hirotaka Inoue; Akiko Yoshimatsu; Shigenori Watanabe

doi:10.1016/0006-8993(96)00581-1

Enhancement of dopamine release from the striatum through metabotropic glutamate receptor activation in methamphetamine sensitized rats

Ikumi Arai, Takao Shimazoe, Shigenobu Shibata, Hirotaka Inoue, Akiko Yoshimatsu, Shigenori Watanabe

School of Advanced Science and Engineering

Research output: Contribution to journal › Article › peer-review

37 Citations (Scopus)

Abstract

An intracerebral microdialysis technique was applied to study the effect of metabotropic glutamate receptor (mGluR) agonist on dopamine release in the striatum of methamphetamine (MAP)-sensitized rats. Rats were treated with MAP (1 mg/kg, i.p.) once daily for 6 consecutive days, followed by it 6-day withdrawal. Perfusion of 0.1 mM (1S,3R)-1-aminocyclopentane-trans-1,3-dicarboxylic acid through a microdialysis probe placed in the striatum enhanced the extracellular dopamine level, and induced stereotyped behavior in MAP-sensitized rats. The enhancement of dopamine release and the stereotyped behavior were attenuated by co-perfusion of 0.4 mM RS-α-methyl-4-carboxyphenyl-glycine, a mGluR antagonist. The present results suggest that mGluRs may be involved in the expression of MAP-induced sensitization.

Original language	English
Pages (from-to)	277-280
Number of pages	4
Journal	Brain Research
Volume	729
Issue number	2
DOIs	https://doi.org/10.1016/0006-8993(96)00581-1
Publication status	Published - 1996 Aug 12

Keywords

Dopamine release
Expression
Metabotropic glutamate receptor
Methamphetamine sensitization
Microdialysis
Striatum

ASJC Scopus subject areas

Neuroscience(all)
Molecular Biology
Clinical Neurology
Developmental Biology

Access to Document

10.1016/0006-8993(96)00581-1

Fingerprint Dive into the research topics of 'Enhancement of dopamine release from the striatum through metabotropic glutamate receptor activation in methamphetamine sensitized rats'. Together they form a unique fingerprint.

Cite this

Enhancement of dopamine release from the striatum through metabotropic glutamate receptor activation in methamphetamine sensitized rats. / Arai, Ikumi; Shimazoe, Takao; Shibata, Shigenobu; Inoue, Hirotaka; Yoshimatsu, Akiko; Watanabe, Shigenori.

In: Brain Research, Vol. 729, No. 2, 12.08.1996, p. 277-280.

Research output: Contribution to journal › Article › peer-review

@article{5be581c0d3da421dad691748c90016ec,

title = "Enhancement of dopamine release from the striatum through metabotropic glutamate receptor activation in methamphetamine sensitized rats",

abstract = "An intracerebral microdialysis technique was applied to study the effect of metabotropic glutamate receptor (mGluR) agonist on dopamine release in the striatum of methamphetamine (MAP)-sensitized rats. Rats were treated with MAP (1 mg/kg, i.p.) once daily for 6 consecutive days, followed by it 6-day withdrawal. Perfusion of 0.1 mM (1S,3R)-1-aminocyclopentane-trans-1,3-dicarboxylic acid through a microdialysis probe placed in the striatum enhanced the extracellular dopamine level, and induced stereotyped behavior in MAP-sensitized rats. The enhancement of dopamine release and the stereotyped behavior were attenuated by co-perfusion of 0.4 mM RS-α-methyl-4-carboxyphenyl-glycine, a mGluR antagonist. The present results suggest that mGluRs may be involved in the expression of MAP-induced sensitization.",

keywords = "Dopamine release, Expression, Metabotropic glutamate receptor, Methamphetamine sensitization, Microdialysis, Striatum",

author = "Ikumi Arai and Takao Shimazoe and Shigenobu Shibata and Hirotaka Inoue and Akiko Yoshimatsu and Shigenori Watanabe",

year = "1996",

month = aug,

day = "12",

doi = "10.1016/0006-8993(96)00581-1",

language = "English",

volume = "729",

pages = "277--280",

journal = "Brain Research Protocols",

issn = "0006-8993",

publisher = "Elsevier",

number = "2",

}

TY - JOUR

T1 - Enhancement of dopamine release from the striatum through metabotropic glutamate receptor activation in methamphetamine sensitized rats

AU - Arai, Ikumi

AU - Shimazoe, Takao

AU - Shibata, Shigenobu

AU - Inoue, Hirotaka

AU - Yoshimatsu, Akiko

AU - Watanabe, Shigenori

PY - 1996/8/12

Y1 - 1996/8/12

N2 - An intracerebral microdialysis technique was applied to study the effect of metabotropic glutamate receptor (mGluR) agonist on dopamine release in the striatum of methamphetamine (MAP)-sensitized rats. Rats were treated with MAP (1 mg/kg, i.p.) once daily for 6 consecutive days, followed by it 6-day withdrawal. Perfusion of 0.1 mM (1S,3R)-1-aminocyclopentane-trans-1,3-dicarboxylic acid through a microdialysis probe placed in the striatum enhanced the extracellular dopamine level, and induced stereotyped behavior in MAP-sensitized rats. The enhancement of dopamine release and the stereotyped behavior were attenuated by co-perfusion of 0.4 mM RS-α-methyl-4-carboxyphenyl-glycine, a mGluR antagonist. The present results suggest that mGluRs may be involved in the expression of MAP-induced sensitization.

AB - An intracerebral microdialysis technique was applied to study the effect of metabotropic glutamate receptor (mGluR) agonist on dopamine release in the striatum of methamphetamine (MAP)-sensitized rats. Rats were treated with MAP (1 mg/kg, i.p.) once daily for 6 consecutive days, followed by it 6-day withdrawal. Perfusion of 0.1 mM (1S,3R)-1-aminocyclopentane-trans-1,3-dicarboxylic acid through a microdialysis probe placed in the striatum enhanced the extracellular dopamine level, and induced stereotyped behavior in MAP-sensitized rats. The enhancement of dopamine release and the stereotyped behavior were attenuated by co-perfusion of 0.4 mM RS-α-methyl-4-carboxyphenyl-glycine, a mGluR antagonist. The present results suggest that mGluRs may be involved in the expression of MAP-induced sensitization.

KW - Dopamine release

KW - Expression

KW - Metabotropic glutamate receptor

KW - Methamphetamine sensitization

KW - Microdialysis

KW - Striatum

UR - http://www.scopus.com/inward/record.url?scp=0030581318&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030581318&partnerID=8YFLogxK

U2 - 10.1016/0006-8993(96)00581-1

DO - 10.1016/0006-8993(96)00581-1

M3 - Article

C2 - 8877000

AN - SCOPUS:0030581318

VL - 729

SP - 277

EP - 280

JO - Brain Research Protocols

JF - Brain Research Protocols

SN - 0006-8993

IS - 2

ER -