Enhancement of dopamine release from the striatum through metabotropic glutamate receptor activation in methamphetamine sensitized rats

Ikumi Arai, Takao Shimazoe, Shigenobu Shibata, Hirotaka Inoue, Akiko Yoshimatsu, Shigenori Watanabe

    Research output: Contribution to journalArticle

    37 Citations (Scopus)

    Abstract

    An intracerebral microdialysis technique was applied to study the effect of metabotropic glutamate receptor (mGluR) agonist on dopamine release in the striatum of methamphetamine (MAP)-sensitized rats. Rats were treated with MAP (1 mg/kg, i.p.) once daily for 6 consecutive days, followed by it 6-day withdrawal. Perfusion of 0.1 mM (1S,3R)-1-aminocyclopentane-trans-1,3-dicarboxylic acid through a microdialysis probe placed in the striatum enhanced the extracellular dopamine level, and induced stereotyped behavior in MAP-sensitized rats. The enhancement of dopamine release and the stereotyped behavior were attenuated by co-perfusion of 0.4 mM RS-α-methyl-4-carboxyphenyl-glycine, a mGluR antagonist. The present results suggest that mGluRs may be involved in the expression of MAP-induced sensitization.

    Original languageEnglish
    Pages (from-to)277-280
    Number of pages4
    JournalBrain Research
    Volume729
    Issue number2
    DOIs
    Publication statusPublished - 1996 Aug 12

    Fingerprint

    Metabotropic Glutamate Receptors
    Methamphetamine
    Dopamine
    Stereotyped Behavior
    Microdialysis
    Perfusion
    Excitatory Amino Acid Agonists
    Excitatory Amino Acid Antagonists

    Keywords

    • Dopamine release
    • Expression
    • Metabotropic glutamate receptor
    • Methamphetamine sensitization
    • Microdialysis
    • Striatum

    ASJC Scopus subject areas

    • Neuroscience(all)

    Cite this

    Enhancement of dopamine release from the striatum through metabotropic glutamate receptor activation in methamphetamine sensitized rats. / Arai, Ikumi; Shimazoe, Takao; Shibata, Shigenobu; Inoue, Hirotaka; Yoshimatsu, Akiko; Watanabe, Shigenori.

    In: Brain Research, Vol. 729, No. 2, 12.08.1996, p. 277-280.

    Research output: Contribution to journalArticle

    Arai, Ikumi ; Shimazoe, Takao ; Shibata, Shigenobu ; Inoue, Hirotaka ; Yoshimatsu, Akiko ; Watanabe, Shigenori. / Enhancement of dopamine release from the striatum through metabotropic glutamate receptor activation in methamphetamine sensitized rats. In: Brain Research. 1996 ; Vol. 729, No. 2. pp. 277-280.
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