Abstract
An intracerebral microdialysis technique was applied to study the effect of metabotropic glutamate receptor (mGluR) agonist on dopamine release in the striatum of methamphetamine (MAP)-sensitized rats. Rats were treated with MAP (1 mg/kg, i.p.) once daily for 6 consecutive days, followed by it 6-day withdrawal. Perfusion of 0.1 mM (1S,3R)-1-aminocyclopentane-trans-1,3-dicarboxylic acid through a microdialysis probe placed in the striatum enhanced the extracellular dopamine level, and induced stereotyped behavior in MAP-sensitized rats. The enhancement of dopamine release and the stereotyped behavior were attenuated by co-perfusion of 0.4 mM RS-α-methyl-4-carboxyphenyl-glycine, a mGluR antagonist. The present results suggest that mGluRs may be involved in the expression of MAP-induced sensitization.
| Original language | English |
|---|---|
| Pages (from-to) | 277-280 |
| Number of pages | 4 |
| Journal | Brain Research |
| Volume | 729 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 1996 Aug 12 |
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Keywords
- Dopamine release
- Expression
- Metabotropic glutamate receptor
- Methamphetamine sensitization
- Microdialysis
- Striatum
ASJC Scopus subject areas
- Neuroscience(all)
Cite this
Enhancement of dopamine release from the striatum through metabotropic glutamate receptor activation in methamphetamine sensitized rats. / Arai, Ikumi; Shimazoe, Takao; Shibata, Shigenobu; Inoue, Hirotaka; Yoshimatsu, Akiko; Watanabe, Shigenori.
In: Brain Research, Vol. 729, No. 2, 12.08.1996, p. 277-280.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Enhancement of dopamine release from the striatum through metabotropic glutamate receptor activation in methamphetamine sensitized rats
AU - Arai, Ikumi
AU - Shimazoe, Takao
AU - Shibata, Shigenobu
AU - Inoue, Hirotaka
AU - Yoshimatsu, Akiko
AU - Watanabe, Shigenori
PY - 1996/8/12
Y1 - 1996/8/12
N2 - An intracerebral microdialysis technique was applied to study the effect of metabotropic glutamate receptor (mGluR) agonist on dopamine release in the striatum of methamphetamine (MAP)-sensitized rats. Rats were treated with MAP (1 mg/kg, i.p.) once daily for 6 consecutive days, followed by it 6-day withdrawal. Perfusion of 0.1 mM (1S,3R)-1-aminocyclopentane-trans-1,3-dicarboxylic acid through a microdialysis probe placed in the striatum enhanced the extracellular dopamine level, and induced stereotyped behavior in MAP-sensitized rats. The enhancement of dopamine release and the stereotyped behavior were attenuated by co-perfusion of 0.4 mM RS-α-methyl-4-carboxyphenyl-glycine, a mGluR antagonist. The present results suggest that mGluRs may be involved in the expression of MAP-induced sensitization.
AB - An intracerebral microdialysis technique was applied to study the effect of metabotropic glutamate receptor (mGluR) agonist on dopamine release in the striatum of methamphetamine (MAP)-sensitized rats. Rats were treated with MAP (1 mg/kg, i.p.) once daily for 6 consecutive days, followed by it 6-day withdrawal. Perfusion of 0.1 mM (1S,3R)-1-aminocyclopentane-trans-1,3-dicarboxylic acid through a microdialysis probe placed in the striatum enhanced the extracellular dopamine level, and induced stereotyped behavior in MAP-sensitized rats. The enhancement of dopamine release and the stereotyped behavior were attenuated by co-perfusion of 0.4 mM RS-α-methyl-4-carboxyphenyl-glycine, a mGluR antagonist. The present results suggest that mGluRs may be involved in the expression of MAP-induced sensitization.
KW - Dopamine release
KW - Expression
KW - Metabotropic glutamate receptor
KW - Methamphetamine sensitization
KW - Microdialysis
KW - Striatum
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U2 - 10.1016/S0006-8993(96)00581-1
DO - 10.1016/S0006-8993(96)00581-1
M3 - Article
VL - 729
SP - 277
EP - 280
JO - Brain Research
JF - Brain Research
SN - 0006-8993
IS - 2
ER -