Enhancement of hemostatic ability of dodecapeptide-conjugated phospholipid vesicles by encapsulation of a platelet aggregation-induced factor

Yosuke Okamura, Ippei Maekawa, Makoto Handa, Yasuo Ikeda, Shinji Takeoka

Research output: Contribution to conferencePaper

Abstract

We conjugated dodecapeptide (H12); a part of the amino acid sequence of fibrinogen, to the terminal of a part of polyethylenglycol chains which modified the surface of the phospholipids vesicles. In this report, we further encapsulated ADP; platelet aggregation-induced factor in the vesicle to enhance the hemostasis of thrombocytopenic rats.

Original languageEnglish
Number of pages1
Publication statusPublished - 2006 Oct 19
Event55th SPSJ Annual Meeting - Nagoya, Japan
Duration: 2006 May 242006 May 26

Conference

Conference55th SPSJ Annual Meeting
CountryJapan
CityNagoya
Period06/5/2406/5/26

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Keywords

  • Dodecapeptide (H12)
  • Haemostatic effect.
  • Phospholipid vesicles
  • Platelet substitutes
  • Release property

ASJC Scopus subject areas

  • Engineering(all)

Cite this

Okamura, Y., Maekawa, I., Handa, M., Ikeda, Y., & Takeoka, S. (2006). Enhancement of hemostatic ability of dodecapeptide-conjugated phospholipid vesicles by encapsulation of a platelet aggregation-induced factor. Paper presented at 55th SPSJ Annual Meeting, Nagoya, Japan.