Enhancement of hemostatic ability of dodecapeptide-conjugated phospholipid vesicles by encapsulation of a platelet aggregation-induced factor

Yosuke Okamura, Ippei Maekawa, Makoto Handa, Yasuo Ikeda, Shinji Takeoka

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Abstract

    We conjugated dodecapeptide (H12); a part of the amino acid sequence of fibrinogen, to the terminal of a part of polyethylenglycol chains which modified the surface of the phospholipids vesicles. In this report, we further encapsulated ADP; platelet aggregation-induced factor in the vesicle to enhance the hemostasis of thrombocytopenic rats.

    Original languageEnglish
    Title of host publicationPolymer Preprints, Japan
    Pages1927
    Number of pages1
    Volume55
    Edition1
    Publication statusPublished - 2006
    Event55th SPSJ Annual Meeting - Nagoya
    Duration: 2006 May 242006 May 26

    Other

    Other55th SPSJ Annual Meeting
    CityNagoya
    Period06/5/2406/5/26

    Fingerprint

    Administrative data processing
    Phospholipids
    Platelets
    Encapsulation
    Amino acids
    Rats
    Agglomeration

    Keywords

    • Dodecapeptide (H12)
    • Haemostatic effect.
    • Phospholipid vesicles
    • Platelet substitutes
    • Release property

    ASJC Scopus subject areas

    • Engineering(all)

    Cite this

    Okamura, Y., Maekawa, I., Handa, M., Ikeda, Y., & Takeoka, S. (2006). Enhancement of hemostatic ability of dodecapeptide-conjugated phospholipid vesicles by encapsulation of a platelet aggregation-induced factor. In Polymer Preprints, Japan (1 ed., Vol. 55, pp. 1927)

    Enhancement of hemostatic ability of dodecapeptide-conjugated phospholipid vesicles by encapsulation of a platelet aggregation-induced factor. / Okamura, Yosuke; Maekawa, Ippei; Handa, Makoto; Ikeda, Yasuo; Takeoka, Shinji.

    Polymer Preprints, Japan. Vol. 55 1. ed. 2006. p. 1927.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Okamura, Y, Maekawa, I, Handa, M, Ikeda, Y & Takeoka, S 2006, Enhancement of hemostatic ability of dodecapeptide-conjugated phospholipid vesicles by encapsulation of a platelet aggregation-induced factor. in Polymer Preprints, Japan. 1 edn, vol. 55, pp. 1927, 55th SPSJ Annual Meeting, Nagoya, 06/5/24.
    Okamura, Yosuke ; Maekawa, Ippei ; Handa, Makoto ; Ikeda, Yasuo ; Takeoka, Shinji. / Enhancement of hemostatic ability of dodecapeptide-conjugated phospholipid vesicles by encapsulation of a platelet aggregation-induced factor. Polymer Preprints, Japan. Vol. 55 1. ed. 2006. pp. 1927
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    AU - Ikeda, Yasuo

    AU - Takeoka, Shinji

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