Enhancing the mechanical properties of guanosine-based supramolecular hydrogels with guanosine-containing polymers

Amanda E. Way, Angie B. Korpusik, Taylor B. Dorsey, Lauren E. Buerkle, Horst A. Von Recum, Stuart J. Rowan

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

We demonstrate that multivalent, polymeric 8-methoxyguanosine derivatives based on poly(dimethylacrylamide) can enhance the mechanical properties of the low molecular weight hydrogelator 8-methoxy-2′,3′,5′-tri-O- acetylguanosine at biologically relevant salt concentrations. It is proposed that these nongelling polymeric derivatives, under the conditions studied, can result in a significant enhancement of these supramolecular gels (e.g., for gels containing 1 wt % gelator G′ can be increased from ca. 2000 Pa with no additive to 80 000 Pa) by acting as supramolecular cross-linking units. Two competing mechanisms appear to play a role in these cogels. At low polymer concentrations the guanosine-containing polymers tend to act more as solubilizing agents for the gelator, thus weakening the gels, while at high guanosine-containing polymer concentrations the gels show a marked enhancement in mechanical properties consistent with them acting as supramolecular cross-linking agents. As such, the thermomechanical properties of these cogels depend on both the polymer:low molecular weight gelator ratio and the number of 8-methoxyguanosine repeat units present in the polymer additive. Thus, these polymeric guanosine-based additives impart the ability to tailor both the modulus and shear sensitivity of the gels. For example, cogels with a modulus ranging between ca. 95 and 80 000 Pa can be obtained through judicious selection of the type and amount of polymer additive.

Original languageEnglish
Pages (from-to)1810-1818
Number of pages9
JournalMacromolecules
Volume47
Issue number5
DOIs
Publication statusPublished - 2014 Mar 11
Externally publishedYes

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Hydrogels
Guanosine
Polymers
Gels
Mechanical properties
Molecular weight
Derivatives
Salts

ASJC Scopus subject areas

  • Organic Chemistry
  • Materials Chemistry
  • Polymers and Plastics
  • Inorganic Chemistry

Cite this

Way, A. E., Korpusik, A. B., Dorsey, T. B., Buerkle, L. E., Von Recum, H. A., & Rowan, S. J. (2014). Enhancing the mechanical properties of guanosine-based supramolecular hydrogels with guanosine-containing polymers. Macromolecules, 47(5), 1810-1818. https://doi.org/10.1021/ma402618z

Enhancing the mechanical properties of guanosine-based supramolecular hydrogels with guanosine-containing polymers. / Way, Amanda E.; Korpusik, Angie B.; Dorsey, Taylor B.; Buerkle, Lauren E.; Von Recum, Horst A.; Rowan, Stuart J.

In: Macromolecules, Vol. 47, No. 5, 11.03.2014, p. 1810-1818.

Research output: Contribution to journalArticle

Way, AE, Korpusik, AB, Dorsey, TB, Buerkle, LE, Von Recum, HA & Rowan, SJ 2014, 'Enhancing the mechanical properties of guanosine-based supramolecular hydrogels with guanosine-containing polymers', Macromolecules, vol. 47, no. 5, pp. 1810-1818. https://doi.org/10.1021/ma402618z
Way, Amanda E. ; Korpusik, Angie B. ; Dorsey, Taylor B. ; Buerkle, Lauren E. ; Von Recum, Horst A. ; Rowan, Stuart J. / Enhancing the mechanical properties of guanosine-based supramolecular hydrogels with guanosine-containing polymers. In: Macromolecules. 2014 ; Vol. 47, No. 5. pp. 1810-1818.
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