Enlargement of the Anterior Horn of the Lateral Ventricle in Schizophrenic Patients: Chronological and Morphometrical Studies

Hiroyasu Shiraishi, Junzo Koizumi, Kojiro Ofuku, Toshihito Suzuki, Kiichiro Saito, Takabumi Hori, Terumi Ikuta, Koichi Kase, Masashi Hori

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5 Citations (Scopus)


Abstract: The anterior horn and lateral ventricular sizes of the brain CT were selected for measurement and comparison between 47 schizophrenic patients and 48 neurotic cases, which constituted the control subjects. The ventricular brain ratio (VBR) and the linear ratio (LR 1–6) in multiple age groups were calculated, analyzed and compared using the Student's t test, the two‐way ANOVA and Bonferroni's methods. It was found that the VBR of the anterior horn and modified bicaudate cerebroventricular index of the teenage schizophrenics were significantly greater than those of the teenage controls (p < 0.01) and the ventricular sizes were not associated with the different stages of age except for the cases of the teenage group. These results support the hypothesis of previous investigators that the ventricular enlargement is present early in the course of schizophrenia and provide additional evidence that in teenage schizophrenic patients there is a tendency of the enlargement of the anterior horn of the lateral ventricle which may be related with a morphological vulnerability in the prefrontal cortex.

Original languageEnglish
Pages (from-to)693-702
Number of pages10
JournalPsychiatry and Clinical Neurosciences
Issue number4
Publication statusPublished - 1990 Dec



  • anterior horn enlargement
  • computed tomography
  • planimetry
  • teenage schizophrenics
  • ventricular brain and linear ratios

ASJC Scopus subject areas

  • Neuroscience(all)
  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health

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