Enterotypes in the landscape of gut microbial community composition

Paul I. Costea, Falk Hildebrand, Arumugam Manimozhiyan, Fredrik Bäckhed, Martin J. Blaser, Frederic D. Bushman, Willem M. De Vos, S. Dusko Ehrlich, Claire M. Fraser, Masahira Hattori, Curtis Huttenhower, Ian B. Jeffery, Dan Knights, James D. Lewis, Ruth E. Ley, Howard Ochman, Paul W. O'Toole, Christopher Quince, David A. Relman, Fergus Shanahan & 9 others Shinichi Sunagawa, Jun Wang, George M. Weinstock, Gary D. Wu, Georg Zeller, Liping Zhao, Jeroen Raes, Rob Knight, Peer Bork

    Research output: Contribution to journalArticle

    59 Citations (Scopus)

    Abstract

    Population stratification is a useful approach for a better understanding of complex biological problems in human health and wellbeing. The proposal that such stratification applies to the human gut microbiome, in the form of distinct community composition types termed enterotypes, has been met with both excitement and controversy. In view of accumulated data and re-analyses since the original work, we revisit the concept of enterotypes, discuss different methods of dividing up the landscape of possible microbiome configurations, and put these concepts into functional, ecological and medical contexts. As enterotypes are of use in describing the gut microbial community landscape and may become relevant in clinical practice, we aim to reconcile differing views and encourage a balanced application of the concept.

    Original languageEnglish
    Pages (from-to)8-16
    Number of pages9
    JournalNature Microbiology
    Volume3
    Issue number1
    DOIs
    Publication statusPublished - 2017 Jan 1

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    Microbiota
    Health
    Population
    Gastrointestinal Microbiome

    ASJC Scopus subject areas

    • Microbiology
    • Immunology
    • Applied Microbiology and Biotechnology
    • Genetics
    • Microbiology (medical)
    • Cell Biology

    Cite this

    Costea, P. I., Hildebrand, F., Manimozhiyan, A., Bäckhed, F., Blaser, M. J., Bushman, F. D., ... Bork, P. (2017). Enterotypes in the landscape of gut microbial community composition. Nature Microbiology, 3(1), 8-16. https://doi.org/10.1038/s41564-017-0072-8

    Enterotypes in the landscape of gut microbial community composition. / Costea, Paul I.; Hildebrand, Falk; Manimozhiyan, Arumugam; Bäckhed, Fredrik; Blaser, Martin J.; Bushman, Frederic D.; De Vos, Willem M.; Ehrlich, S. Dusko; Fraser, Claire M.; Hattori, Masahira; Huttenhower, Curtis; Jeffery, Ian B.; Knights, Dan; Lewis, James D.; Ley, Ruth E.; Ochman, Howard; O'Toole, Paul W.; Quince, Christopher; Relman, David A.; Shanahan, Fergus; Sunagawa, Shinichi; Wang, Jun; Weinstock, George M.; Wu, Gary D.; Zeller, Georg; Zhao, Liping; Raes, Jeroen; Knight, Rob; Bork, Peer.

    In: Nature Microbiology, Vol. 3, No. 1, 01.01.2017, p. 8-16.

    Research output: Contribution to journalArticle

    Costea, PI, Hildebrand, F, Manimozhiyan, A, Bäckhed, F, Blaser, MJ, Bushman, FD, De Vos, WM, Ehrlich, SD, Fraser, CM, Hattori, M, Huttenhower, C, Jeffery, IB, Knights, D, Lewis, JD, Ley, RE, Ochman, H, O'Toole, PW, Quince, C, Relman, DA, Shanahan, F, Sunagawa, S, Wang, J, Weinstock, GM, Wu, GD, Zeller, G, Zhao, L, Raes, J, Knight, R & Bork, P 2017, 'Enterotypes in the landscape of gut microbial community composition', Nature Microbiology, vol. 3, no. 1, pp. 8-16. https://doi.org/10.1038/s41564-017-0072-8
    Costea PI, Hildebrand F, Manimozhiyan A, Bäckhed F, Blaser MJ, Bushman FD et al. Enterotypes in the landscape of gut microbial community composition. Nature Microbiology. 2017 Jan 1;3(1):8-16. https://doi.org/10.1038/s41564-017-0072-8
    Costea, Paul I. ; Hildebrand, Falk ; Manimozhiyan, Arumugam ; Bäckhed, Fredrik ; Blaser, Martin J. ; Bushman, Frederic D. ; De Vos, Willem M. ; Ehrlich, S. Dusko ; Fraser, Claire M. ; Hattori, Masahira ; Huttenhower, Curtis ; Jeffery, Ian B. ; Knights, Dan ; Lewis, James D. ; Ley, Ruth E. ; Ochman, Howard ; O'Toole, Paul W. ; Quince, Christopher ; Relman, David A. ; Shanahan, Fergus ; Sunagawa, Shinichi ; Wang, Jun ; Weinstock, George M. ; Wu, Gary D. ; Zeller, Georg ; Zhao, Liping ; Raes, Jeroen ; Knight, Rob ; Bork, Peer. / Enterotypes in the landscape of gut microbial community composition. In: Nature Microbiology. 2017 ; Vol. 3, No. 1. pp. 8-16.
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