Entrainment of mouse peripheral circadian clocks to <24 h feeding/fasting cycles under 24 h light/dark conditions

Yutaro Hamaguchi, Yu Tahara, Hiroaki Kuroda, Atsushi Haraguchi, Shigenobu Shibata

Research output: Contribution to journalArticle

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Abstract

The circadian clock system in peripheral tissues can endogenously oscillate and is entrained by the light-dark and fasting-feeding cycles in mammals. Although the systems range of entrainment to light-dark cycles with a non-24 h (<24 h) interval has been studied, the range of entrainment to fasting-feeding cycles with shorter periods (<24 h) has not been investigated in peripheral molecular clocks. In the present study, we measured this range by monitoring the mouse peripheral PER2::LUCIFERASE rhythm in vivo at different periods under each feeding cycle (Tau (T) = 15-24 h) under normal light-dark conditions. Peripheral clocks could be entrained to the feeding cycle with T = 22-24 h, but not to that with T = 15-21 h. Under the feeding cycle with T = 15-18 h, the peripheral clocks oscillated at near the 24-h period, suggesting that they were entrained to the light-dark cycle. Thus, for the first time, we demonstrated the range of entrainment to the non-24 h feeding cycle, and that the circadian range (T = 22-24 h) of feeding stimulus is necessary for peripheral molecular clock entrainment under light-dark cycles.

Original languageEnglish
Article number14207
JournalScientific Reports
Volume5
DOIs
Publication statusPublished - 2015 Sep 23

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Circadian Clocks
Photoperiod
Fasting
Light
Mammals

ASJC Scopus subject areas

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Entrainment of mouse peripheral circadian clocks to <24 h feeding/fasting cycles under 24 h light/dark conditions. / Hamaguchi, Yutaro; Tahara, Yu; Kuroda, Hiroaki; Haraguchi, Atsushi; Shibata, Shigenobu.

In: Scientific Reports, Vol. 5, 14207, 23.09.2015.

Research output: Contribution to journalArticle

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