Environmental estrogens and reproductive biology in amphibians

G. Mosconi, O. Carnevali, M. F. Franzoni, E. Cottone, I. Lutz, W. Kloas, K. Yamamoto, S. Kikuyama, A. M. Polzonetti-Magni

    Research output: Contribution to journalArticle

    82 Citations (Scopus)

    Abstract

    In this paper, the effects of an estrogenic compound, 4-nonyl-phenol (NP), on the amphibians Rana esculenta and Triturus carnifex are described together with those on sexual differentiation in Xenopus laevis. NP increased plasma vitellogenin in male frogs and newts in a dose-related manner; moreover, inhibitory effects on gonadotropin and prolactin (PRL) secretion by pituitary were found together with an elevation of plasma androgens. NP treatment also caused a remarkable increase in number of prolactin-immunolabeled cells, suggesting that xenoestrogen might induce, at least in the newt pituitary, a PRL accumulation possibly due to a reduction of the hormone release. In addition, both NP and bisphenol A caused feminization by increasing the percentage of female phenotypes in X. laevis, and the in vivo effects were more pronounced than those of estradiol-17β.

    Original languageEnglish
    Pages (from-to)125-129
    Number of pages5
    JournalGeneral and Comparative Endocrinology
    Volume126
    Issue number2
    DOIs
    Publication statusPublished - 2002

    Fingerprint

    Amphibians
    phenol
    estrogens
    amphibians
    Estrogens
    prolactin
    Prolactin
    Salamandridae
    Biological Sciences
    Xenopus laevis
    salamanders and newts
    xenoestrogens
    Triturus
    Feminization
    Rana esculenta
    feminization
    Vitellogenins
    bisphenol A
    estrogenic properties
    Sex Differentiation

    Keywords

    • Amphibians
    • Reproduction
    • Xenoestrogens

    ASJC Scopus subject areas

    • Endocrinology

    Cite this

    Mosconi, G., Carnevali, O., Franzoni, M. F., Cottone, E., Lutz, I., Kloas, W., ... Polzonetti-Magni, A. M. (2002). Environmental estrogens and reproductive biology in amphibians. General and Comparative Endocrinology, 126(2), 125-129. https://doi.org/10.1006/gcen.2002.7781

    Environmental estrogens and reproductive biology in amphibians. / Mosconi, G.; Carnevali, O.; Franzoni, M. F.; Cottone, E.; Lutz, I.; Kloas, W.; Yamamoto, K.; Kikuyama, S.; Polzonetti-Magni, A. M.

    In: General and Comparative Endocrinology, Vol. 126, No. 2, 2002, p. 125-129.

    Research output: Contribution to journalArticle

    Mosconi, G, Carnevali, O, Franzoni, MF, Cottone, E, Lutz, I, Kloas, W, Yamamoto, K, Kikuyama, S & Polzonetti-Magni, AM 2002, 'Environmental estrogens and reproductive biology in amphibians', General and Comparative Endocrinology, vol. 126, no. 2, pp. 125-129. https://doi.org/10.1006/gcen.2002.7781
    Mosconi G, Carnevali O, Franzoni MF, Cottone E, Lutz I, Kloas W et al. Environmental estrogens and reproductive biology in amphibians. General and Comparative Endocrinology. 2002;126(2):125-129. https://doi.org/10.1006/gcen.2002.7781
    Mosconi, G. ; Carnevali, O. ; Franzoni, M. F. ; Cottone, E. ; Lutz, I. ; Kloas, W. ; Yamamoto, K. ; Kikuyama, S. ; Polzonetti-Magni, A. M. / Environmental estrogens and reproductive biology in amphibians. In: General and Comparative Endocrinology. 2002 ; Vol. 126, No. 2. pp. 125-129.
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