Enzyme inhibitors from marine invertebrates

Youichi Nakao, Nobuhiro Fusetani

Research output: Contribution to journalArticle

60 Citations (Scopus)

Abstract

Marine invertebrates are rich sources of small molecules with unique chemical skeletons and potent bioactivities. Historically, such compounds were discovered mainly through the use of assays for phenotype-oriented activities, such as cytotoxicity or antimicrobial effects. More recently, target-oriented searches for bioactive substances, as exemplified by enzyme inhibitors, have become much more common, given a growing need for small-molecule inhibitors essential for studies of complex processes at the interface of chemistry and biology. In this review, selected enzyme inhibitors from marine invertebrates are presented.

Original languageEnglish
Pages (from-to)689-710
Number of pages22
JournalJournal of Natural Products
Volume70
Issue number4
DOIs
Publication statusPublished - 2007 Apr
Externally publishedYes

Fingerprint

enzyme inhibitors
Enzyme Inhibitors
Invertebrates
invertebrates
Molecules
anti-infective properties
Cytotoxicity
Bioactivity
Skeleton
skeleton
cytotoxicity
Assays
chemistry
Phenotype
phenotype
Biological Sciences
assays

ASJC Scopus subject areas

  • Plant Science
  • Chemistry (miscellaneous)
  • Drug Discovery
  • Organic Chemistry
  • Pharmacology

Cite this

Enzyme inhibitors from marine invertebrates. / Nakao, Youichi; Fusetani, Nobuhiro.

In: Journal of Natural Products, Vol. 70, No. 4, 04.2007, p. 689-710.

Research output: Contribution to journalArticle

Nakao, Youichi ; Fusetani, Nobuhiro. / Enzyme inhibitors from marine invertebrates. In: Journal of Natural Products. 2007 ; Vol. 70, No. 4. pp. 689-710.
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