Enzyme inhibitors from marine invertebrates

Youichi Nakao, Nobuhiro Fusetani

    Research output: Chapter in Book/Report/Conference proceedingChapter

    Abstract

    Marine invertebrates are the rich source of small molecules with unique chemical skeletons and potent bioactivities; however, the major biological activities tested for marine natural products have been mainly limited to the traditional phenotype-oriented bioactivities such as cytotoxicity or antimicrobial activities. Enzyme inhibition is the target-oriented bioactivity and small molecule inhibitors are quite useful for controlling biological processes and understanding complicated biological phenomena. Recently, it has been recognized that the natural products are superior source of small molecule probes useful for the chemical biology. Especially, marine-derived enzyme inhibitors still remain to be fully investigated in spite of their high potentials as a source of unique compounds. In this chapter, selected enzyme inhibitors from marine invertebrates are described.

    Original languageEnglish
    Title of host publicationHandbook of Marine Natural Products
    PublisherSpringer Netherlands
    Pages1145-1229
    Number of pages85
    ISBN (Electronic)9789048138340
    ISBN (Print)9789048138333
    DOIs
    Publication statusPublished - 2012 Jan 1

    Fingerprint

    Biological Phenomena
    Enzyme Inhibitors
    Invertebrates
    Bioactivity
    Biological Products
    Skeleton
    Molecules
    Phenotype
    Enzyme inhibition
    Enzymes
    Cytotoxicity

    ASJC Scopus subject areas

    • Biochemistry, Genetics and Molecular Biology(all)

    Cite this

    Nakao, Y., & Fusetani, N. (2012). Enzyme inhibitors from marine invertebrates. In Handbook of Marine Natural Products (pp. 1145-1229). Springer Netherlands. https://doi.org/10.1007/978-90-481-3834-0_23

    Enzyme inhibitors from marine invertebrates. / Nakao, Youichi; Fusetani, Nobuhiro.

    Handbook of Marine Natural Products. Springer Netherlands, 2012. p. 1145-1229.

    Research output: Chapter in Book/Report/Conference proceedingChapter

    Nakao, Y & Fusetani, N 2012, Enzyme inhibitors from marine invertebrates. in Handbook of Marine Natural Products. Springer Netherlands, pp. 1145-1229. https://doi.org/10.1007/978-90-481-3834-0_23
    Nakao Y, Fusetani N. Enzyme inhibitors from marine invertebrates. In Handbook of Marine Natural Products. Springer Netherlands. 2012. p. 1145-1229 https://doi.org/10.1007/978-90-481-3834-0_23
    Nakao, Youichi ; Fusetani, Nobuhiro. / Enzyme inhibitors from marine invertebrates. Handbook of Marine Natural Products. Springer Netherlands, 2012. pp. 1145-1229
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