Enzyme models: Design and selection

Stuart J. Rowan, Jeremy K M Sanders

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

There are two approaches to the discovery of enzyme mimics, that is identifying molecules that are able to bind substrate(s) and then catalyse reactions. The first approach, often inspired by enzymes themselves, utilises chemical knowledge and experience to design the catalyst. The other approach is to create a library and select the best host of a transition state analogue of the required reaction.

Original languageEnglish
Pages (from-to)483-490
Number of pages8
JournalCurrent Opinion in Chemical Biology
Volume1
Issue number4
Publication statusPublished - 1997 Dec
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry

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  • Cite this

    Rowan, S. J., & Sanders, J. K. M. (1997). Enzyme models: Design and selection. Current Opinion in Chemical Biology, 1(4), 483-490.