Enzyme models: Design and selection

Stuart J. Rowan, Jeremy K M Sanders

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

There are two approaches to the discovery of enzyme mimics, that is identifying molecules that are able to bind substrate(s) and then catalyse reactions. The first approach, often inspired by enzymes themselves, utilises chemical knowledge and experience to design the catalyst. The other approach is to create a library and select the best host of a transition state analogue of the required reaction.

Original languageEnglish
Pages (from-to)483-490
Number of pages8
JournalCurrent Opinion in Chemical Biology
Volume1
Issue number4
Publication statusPublished - 1997 Dec
Externally publishedYes

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Enzymes
Libraries
Catalysts
Molecules
Substrates

ASJC Scopus subject areas

  • Biochemistry

Cite this

Rowan, S. J., & Sanders, J. K. M. (1997). Enzyme models: Design and selection. Current Opinion in Chemical Biology, 1(4), 483-490.

Enzyme models : Design and selection. / Rowan, Stuart J.; Sanders, Jeremy K M.

In: Current Opinion in Chemical Biology, Vol. 1, No. 4, 12.1997, p. 483-490.

Research output: Contribution to journalArticle

Rowan, SJ & Sanders, JKM 1997, 'Enzyme models: Design and selection', Current Opinion in Chemical Biology, vol. 1, no. 4, pp. 483-490.
Rowan SJ, Sanders JKM. Enzyme models: Design and selection. Current Opinion in Chemical Biology. 1997 Dec;1(4):483-490.
Rowan, Stuart J. ; Sanders, Jeremy K M. / Enzyme models : Design and selection. In: Current Opinion in Chemical Biology. 1997 ; Vol. 1, No. 4. pp. 483-490.
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